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| Name | Class |
|---|---|
| Lundbeck Foundation | OTHER |
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This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.
The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Participants |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heat Stimulation | Device | Heat stimulation at a painful, but to the subject tolerable level. |
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| Measure | Description | Time Frame |
|---|---|---|
| C-fiber excitability | Changes in C-fiber excitability measured in latency changes after electrical stimulation with a paired pulse protocol compared to an unpaired electrical stimulus. | Through study completion, an average of 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Action potential duration (ms) | Averaged analysis from repeated measures of a single nerve fiber signal. | Through study completion, an average of 6 months |
| Action potential amplitude (V) | Averaged analysis from repeated measures of a single nerve fiber signal. |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy Subjects
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexander G Kristensen, MD, PhD | Contact | +45 93 52 28 64 | alexgramm@clin.au.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Pain Research Center | Recruiting | Aarhus N | 8200 | Denmark |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| D010146 | Pain |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Through study completion, an average of 6 months |
| Heart-rate variability (ms) | Comparison of heart-rate variability during experimental pain stimulation and during pain relief. | Through study completion, an average of 6 months |
| Blood pressure variability (mmHg) | Changes in continuous blood pressure measurement averages during experimental pain stimulation and during pain relief.. | Through study completion, an average of 6 months |
| Sympathetic Skin Response (V) | Amplitude of Sympathetic skin response during pain stimulation and relief respectively. | Through study completion, an average of 6 months |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |