Characterization of Secondary Hyperalgesia in Healthy Volunteers

Characterization of Secondary Hyperalgesia in Healthy Volunteers

In this prospective trial we aim to investigate the intra-individual and inter-individual variance in secondary hyperalgesia following pain elicited by the experimental pain model: Brief Thermal Sensitization.

Furthermore we wish to investigate how precise the psychological tests, Pain Catastrophizing Scale and Hospital Anxiety and Depression Scale predict the size of the area of secondary hyperalgesia.

Inclusion Criteria:

• Age >18 years and <35 years
• Speak and understand Danish
• Male gender
• Test subjects who have understood and signed the informed consent
• No prescription medicine during the last 30 days

Exclusion Criteria:

• Test subjects that cannot cooperate to the test
• Test subjects with an alcohol and/or substance abuse, assessed by the investigator
• Test subjects, who have consumed one or several types of analgesics 2 <days before the study
• Test subjects, who have consumed antidepressant medication during the last 30 days before the study
• Test subjects with chronic pain
• Test subjects with psychiatric diagnoses
• Test subjects with tattoos on the extremities
• Body Mass Index of >30 or <18