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To evaluate choroidal and choriocapillaris changes in patients with central serous chorioretinopathy, undergone sub threshold micropulse laser treatment, following any improvement with conservative therapy with Acetazolamide and/or Eplerenone
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Subthreshold Micropulse Laser Treatment | Other | Subthreshold micropulse laser treatment consists in 33 spots of 100 microns, distance among each spot of 2.50 microns, duration of 200 sec, power of 250 milliwatt (mW) duty cycle 5%. |
| Measure | Description | Time Frame |
|---|---|---|
| Vessel density changes | Evaluation of changes in vessel density of choriocapillaris by optical coherence tomography (OCT) angiography before and after treatment | 12 and 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Choroidal thickness | Evaluation of changes in choroidal thickness before and after treatment. | 12 and 24 months |
| Choroidal thickness and vessel density | Correlation among changes in choroidal thickness and changes in vessel density of choriocapillary with best corrected visual acuity. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients older than 18 years old, with diagnosis of central serous chorioretinopathy since at least 6 months, undergone Acetazolamide and/or Eplerenone therapy with no improvement after 6 months.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maria Cristina Savastano, MD, PhD | Contact | (+39)063015 | mariacristinasavastano@policlinicogemelli.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Policlinico Agostino Gemelli, IRCCS | Recruiting | Roma | R | 00168 | Italy |
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| ID | Term |
|---|---|
| D056833 | Central Serous Chorioretinopathy |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| 12 and 24 months |
| Qualitative analysis of retino-choroidal vascularization with identification of vascular pattern | To qualitatively evaluate the vascular patterns using optical coherence tomography (OCT) - angiography and to verify if a particular one is associated with a greater response to subthreshold micropulse laser treatment. | 12 and 24 months |
| Metamorphopsia | Evaluation of quantitative improvement of metamorphosia by M-CHARTS after treatment. | 12 and 24 months |
| Metamorphopsia and BCVA | Correlation between metamorphopsia and best corrected visual acuity (BCVA) | 12 and 24 months |
| Ellipsoid Zone Integrity | Evaluation of ellipsoid zone integrity by optical coherence tomography (OCT) B scan. | 12 and 24 months |
| Improvement in retinal function | To evaluate the potential improvement in retinal function with mean retinal sensitivity and microperimetry. | 12 and 24 months |
| Quality of life (QoL) | Evaluation of correlation among quality of life parameters assessed by visual function questionnaire (VFQ), stress and relapses and visual acuity. | 12 and 24 months |
| Ellipsoid zone and BCVA | To evaluate the association between ellipsoid zone integrity on optical coherence tomography (OCT) B scan and best corrected visual acuity (BCVA) | 12 and 24 months |