Central serous chorioretinopathy (CSC) is a common eye disease mainly involving the macular area, causing central visual acuity loss. Recently, subthreshold micropulse laser used in treating chronic CSC is proved to be safe and effective. However, some studies indicate that it's less effective than half dose photodynamic therapy (PDT). Certain physicians, including us, think that this may be related to micropulse laser parameters. Thus we need to explore better laser patterns to replace PDT in treating chronic CSC. The aim of this study is to compare the treatment effect of two different patterns of laser parameters (small and regular spot diameter) in treating chronic CSC. In this randomized, double blinded, controlled trial, by comparing the subretinal fluid regression ratio, central retinal thickness, macular microvisual field, macular vascular density, chroidal volume changes and visual acuity of two groups 6 months after micropulse laser treatment, we aim to evaluate the safety and efficacy of refined micropulse laser in treating chronic CSC.

Inclusion Criteria:

• Patients age range 18-50 years
• Patients diagnosed with chronic Central serous chorioretinopathy
• Patients have signed informed consent

Exclusion Criteria:

• A history of other fundus diseases or refractive media opacity
• Patients have underwent other treatment methods for chronic Central serous chorioretinopathy
• Diopter>-6D
• A history of system diseases such as hypertension or diabetes
• A history of using local or systemic corticosteroids