Washed Microbiota Transplantation Alleviates Diabetic Gastrointestinal Motility Disorders: an Efficacy and Safety Study

Washed Microbiota Transplantation Alleviates Diabetic Gastrointestinal Motility Disorders: an Efficacy and Safety Study

The goal of this clinical trial is to learn about effectiveness and safety of washing microbiota transplantation in diabetic gastrointestinal motility disorders participant population. The main questions it aims to answer are:

• The risk factors of diabetic gastrointestinal motility disorders in routine clinical data or biochemical tests.
• The composition of gut microbiota in diabetic gastrointestinal motility disorders patients and potential pathogenic bacteria.
• The efficacy of washing microbiota transplantation in the clinical treatment of diabetic gastrointestinal motility disorders patients and potential factors that may influence treatment outcomes.
• The potential mechanisms of washing microbiota transplantation in treating diabetic gastrointestinal motility disorders patients.

Participants will be collected fasting venous blood and random stool samples before treatment and at week 12 post-treatment, conducting scale assessments before treatment and at weeks 1, 4, and 12 post-treatment.

Inclusion Criteria:

• Clinical diagnosis of type 2 diabetes and diabetic gastrointestinal motility disorder.
• Glycated hemoglobin (HbA1c) < 11.0%.

Exclusion Criteria:

• Insulin dependent diabetes;
• Active infections, antibiotics-using, inflammatory bowel disease, irritable bowel syndrome, or other severe gastrointestinal organic disease;
• Severe diabetic complications;
• Thyroid disease, malignancies, severe cognitive impairment and mental disease;
• Alcohol or substance abuse;
• Pregnancy or lactation.