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The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of the diaphragm.
This is a prospective, single-center study of adult (age ≥18 years) participants undergoing high-resolution esophageal manometry to assess the optimal method of diaphragmatic breathing. Included patients will complete two validated surveys, the Brief Esophageal Dysphagia Questionnaire (BEDQ) and the Gastroesophageal Reflux Disease Questionnaire (GERDQ). Patients will then undergo a standard protocol of supine and upright swallows with high-resolution manometry analyzed according to the Chicago Classification v4.0. After completion of the standard manometry protocol, participants will then perform a protocol assessing different techniques and positions for diaphragmatic breathing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diaphragmatic breathing protocol | Other | All patients will undergo the diaphragmatic breathing protocol with high-resolution esophageal manometry. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| diaphragmatic breathing | Diagnostic Test | Different positions and techniques for diaphragmatic breathing |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pressure at the esophagogastric junction | Measurement of EGJ- contractile integral and diaphragmatic pressure with each exercise/instruction | Measured for each participant during high-resolution esophageal manometry. Data will be collected over the enrollment period of one year. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andree Koop, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Jacksonville | Florida | 32224 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D005764 | Gastroesophageal Reflux |
| D003680 | Deglutition Disorders |
| D015154 | Esophageal Motility Disorders |
| ID | Term |
|---|---|
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010608 | Pharyngeal Diseases |
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| D010038 | Otorhinolaryngologic Diseases |