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the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bone resection |
| ||
| subperiosteal excision |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bone resection | Procedure | patients underwent soft tissue sarcoma excision together with bone resection following either biological or endoprosthesis reconstruction |
|
| Measure | Description | Time Frame |
|---|---|---|
| survival | Whether patient die or not | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until patients died or were loss to follow up. |
| recurrence | whether patients developed local recurrence | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until patients died or were oss to follow up. |
| metastasis | whether patients developed metastasis | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until they died or were loss to follow up. |
| Measure | Description | Time Frame |
|---|---|---|
| functional outcomes | The Musculoskeletal Tumor Society (MSTS) questionnaire for the lower extremity is composed of six items including pain, function, emotional acceptance, use of any external support, walking ability, and gait alteration. Each item is rated in a scale of 0-5. The total score ranges from 0 to 30, with higher scores indicating better function. | MSTS scores were measured every 6 months for the first two years after surgery. After that, MSTS outcomes were measured once every year until patients died or were loss to follow up. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients displayed with thigh soft tissue sarcoma with only cortical contact of the adjacent bone and underwent limb-salvage surgery were included for the study. Patients could be divided into two groups: 1) sub-periosteal tumor excision group and 2) composite bone resection and reconstruction group.
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| Name | Affiliation | Role |
|---|---|---|
| Zhaoming Ye | Second Affiliated Hospital, School of Medicine, Zhejiang University | Principal Investigator |
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| ID | Term |
|---|---|
| D012509 | Sarcoma |
| ID | Term |
|---|---|
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| subperiosteal excision | Procedure | patients underwent sub-periosteal tumor excision combining bone and soft tissue ablation without bone excision |
|