Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Pilot Studies Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. The purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea.

Inclusion Criteria:

• Fitzpatrick Skin Type I - IIII
• Self-identified rosacea or no history of flushing/blushing for controls
• Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.

Exclusion Criteria:

• Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)
• Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)
• Large tattoos in the designated testing areas
• Tanning bed use within last 3 months
• Photodynamic Therapy or UCB treatments in past 3 months
• Female Subjects: pregnant or nursing