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| Name | Class |
|---|---|
| Karolinska Institutet | OTHER |
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"Braining" is a clinical method for physical exercise as adjunctive therapy in psychiatric care. The core components are personnel-led group training sessions and motivating contact with psychiatric staff, as well as measurements and evaluations before and after a training period.
The scientific purpose of this study is to investigate immediate and short-term effects of a booster-session of several Braining classes.
"Braining" is a clinical invention that helps patients in psychiatry to start and execute physical exercise (PE) regularly in psychiatric care. The core components are basic moderate to vigorous aerobic group training sessions and motivational work led by the psychiatric staff. Braining is used as add-on treatment to regular psychiatric care and is included in the patient care plan.
In the present study, the focus is on the acute effects of a booster session of one to three Braining classes on psychiatric symptoms and biomolecular markers as well as impact on motivational factors.
Participants are recruited from the final cohort (N = 51) of the previous retrospective study, (Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety).This final cohort will be contacted to give written consent to partake in the booster session. The Braining classes each have a duration of 30 minutes and are scheduled over the course of a week.
Descriptive data on participating patients will be collected before the booster week. This will include age, gender, diagnoses, employment status. In conjunction with this, basic psychiatric and somatic examinations will be conducted.
During each Braining class, participants' activity level will be measured with a heart rate monitor to ascertain achieving moderate to vigorous intensity. Directly before and after each class, current anxiety level will be measured on a Visual Analogue Scale 0-100.
Within 30 minutes before and after one Braining class, venous blood samples (50 ml) will be taken for biomolecular markers. Blood samples include 1) inflammation markers such as high-sensitivity C-reactive protein hsCRP, 2) Brain-derived neurotrophic factor BDNF, 3) telomerase activity and 4) epigenetic markers.
Before and after the booster week, self-assessments scales for anxiety and depressive symptoms will be administered. Qualitative data on participants' experience as well as motivational factors will be collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical activity | Experimental | Patients are encouraged to participate in physical exercise at the psychiatric unit |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Braining | Behavioral | "Braining" is a clinical invention that helps patients in psychiatry to start and execute physical exercise (PE) regularly in psychiatric care. The core components are basic moderate to vigorous aerobic group training session and motivational work led by the psychiatric staff. Braining is used as add-on treatment to regular psychiatric care and is included in the patient care plan. |
| Measure | Description | Time Frame |
|---|---|---|
| Anxiety Visual Analogue Scale (VAS) | Self-rated anxiety levels on a scale from 0 to 100, where 0 is no anxiety and 100 is maximal anxiety. | Pre- to post-exercise class, timeframe 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Beck Anxiety Inventory BAI | Self-report measure of anxiety during the last week. 21 items, score ranges from 0 to 63 with higher scores indicating more severe anxiety symptoms. | Pre-intervention to post-intervention, timeframe 1 week |
| Montgomery-Ă…sberg Depression Rating Scale MADRS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ă…sa Anger | Contact | +46858580445 | asa.susanna.anger@ki.se |
| Name | Affiliation | Role |
|---|---|---|
| Lina Martinsson | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Region Stockholm, Psykiatri Sydväst (Psychiatric Clinic Psychiatry Southwest) | Stockholm | Stockholm County | 14186 | Sweden |
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| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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|
Clinician-rated scale to assess degree of depressive symptoms. 10 items. Minimum value 0 and maximum value 60, where higher values indicate more depressive symptoms. |
| Pre-intervention to post-intervention, timeframe 1 week |
| High sensitivity C-reactive protein hsCRP | Blood marker of inflammation and infection, mmol/L | Pre- to post-exercise class, timeframe 2 hours |
| Brain-derived neurotrophic factor BDNF | Stimulates and controls neurogenesis | Pre- to post-exercise class, timeframe 2 hours |
| Telomerase activity | Enzyme activity in blood | Pre- to post-exercise class, timeframe 2 hours |
| Motivational factors of continued exercise | Semi-structured interview derived from motivational interviewing | Pre-intervention to post-intervention, timeframe 1 week |