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To compare efficacy of cetylated fatty acid with placebo for reducing postoperative pain after unilateral TKA. The hypothesis is topical cetylated fatty acid can mitigate postoperative pain after TKA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cetylated fatty acid | Experimental | Topical cetylated fatty acid, apply 2 times/day for 6 weeks after operation |
|
| Placebo | Placebo Comparator | Topical placebo, apply 2 times/day for 6 weeks after operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cetylated fatty acid | Drug | use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual analog scale | VAS (0-100) at rest and on motion | post-op Day2 |
| Visual analog scale | VAS (0-100) at rest and on motion | post-op week2 |
| Visual analog scale | VAS (0-100) at rest and on motion | post-op week6 |
| Visual analog scale | VAS (0-100) at rest and on motion | post-op week12 |
| inflammatory marker | ESR and CRP | post-op day2 |
| inflammatory marker | ESR and CRP | post-op week2 |
| inflammatory marker | ESR and CRP | post-op week6 |
| inflammatory marker | ESR and CRP | post-op week12 |
| Knee skin temperature | evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee |
| Measure | Description | Time Frame |
|---|---|---|
| Knee circumference (cm) | Measured by tape at midpoint of patella | post-op Day2 |
| Knee circumference (cm) | Measured by tape at midpoint of patella |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Supakit Kanitnate, M.D. | Contact | 66899853635 | naypeng@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Supakit Kanitnate, MD | Thammasat University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| department of orthopaedic surgery, Faculty of medicine, Thammasat university | Recruiting | Khlong Luang | Changwat Pathum Thani | 066 | Thailand |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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|
| Placebo | Drug | use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb |
|
| post-op Day2 |
| Knee skin temperature | evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee | post-op week2 |
| Knee skin temperature | evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee | post-op week6 |
| Knee skin temperature | evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee | post-op week12 |
| post-op week2 |
| Knee circumference (cm) | Measured by tape at midpoint of patella | post-op week6 |
| Knee circumference (cm) | Measured by tape at midpoint of patella | post-op week12 |
| Knee Range of Motion | Flexion and extension angle | post-op Day2 |
| Knee Range of Motion | Flexion and extension angle | post-op week2 |
| Knee Range of Motion | Flexion and extension angle | post-op week6 |
| Knee Range of Motion | Flexion and extension angle | post-op week12 |
| Modified WOMAC | Total & Subscore | post-op week2 |
| Modified WOMAC | Total & Subscore | post-op week6 |
| Modified WOMAC | Total & Subscore | post-op week12 |
| Thai forgotten joint score | post-op week2 |
| Thai forgotten joint score | post-op week6 |
| Thai forgotten joint score | post-op week12 |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |