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Emerging scientific results show that disrupted functional connectivity in stroke can explain behavioral impairments and predict their recovery over time. However, no technique is yet available for widespread use in clinics to examine how neural synchronization in brain networks is altered in stroke patients. This is crucial to determine favorable prognostic factors and to define individualized rehabilitation protocols. Importantly, the investigators have successfully used high-density electroencephalography (hdEEG) in healthy individuals to measure neural synchronization in brain networks. In this project, the investigators will develop methods and tools based on hdEEG for assessing functional connectivity in stroke patients. These methods and tools will be employed to examine how neural changes occurring after brain lesions explain behavioral impairments. The project will open the way for the use of hdEEG at the patient's bedside, as a neurodiagnostic tool for stroke as well as other brain disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| stroke patients | Other | Resting-state networks obtained through electroencephalography will be analyzed in a group of stroke patients. |
|
| healthy participants | Other | Resting-state networks obtained through electroencephalography will be analyzed in a group of healthy participants. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Connectivity measures | Device | Electroencephalography connectivity measures will be collected and compared in both stroke patients and healthy participants. Connectivity measures will be extracted using these devices: high-density electroencephalography (using either a 128-channel or a 256-channel system) and magnetic resonance imaging. |
| Measure | Description | Time Frame |
|---|---|---|
| High-density electroencephalography measurements (work package 1, 2, and 3) | High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system | Immediately after the recruiting |
| High-density electroencephalography measurements (work package 1, 2, and 3) | High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system | 1 month after the recruiting |
| High-density electroencephalography measurements (work package 1, 2, and 3) | High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system | 2 months after the recruiting |
| High-density electroencephalography measurements (work package 1, 2, and 3) | High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system | 4 months after the recruiting |
| High-density electroencephalography measurements (work package 1, 2, and 3) | High-density electroencephalography measurements, specifically focusing on resting state networks, will be performed using either a 128-channel or a 256-channel system | 6 months after the recruiting |
| Magnetic Resonance Imaging measurement (work package 1, 2, and 3) | Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength measurement (work package 3) | Muscle strength will be measured in the patients by using the Medical Research Council Score | Immediately after the recruiting |
| Muscle strength measurement (work package 3) |
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In this study 125 stroke patients and 45 healthy participants will be recruited at the Institute for Research and Healthcare with a Scientific Character (IRCCS) San Camillo hospital.
Inclusion Criteria (patients):
Inclusion Criteria (healthy participants):
• compliance with magnetic resonance imaging (e.g., no claustrophobia)
Exclusion Criteria (both patients and healthy participants):
• no comorbidities with psychiatric disorders
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dante Mantini | Contact | +39 0412207594 | dante.mantini@hsancamillo.it | |
| Giorgio Arcara | Contact | giorgio.arcara@hsancamillo.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS San Camillo Hospital | Recruiting | Venice | Italy |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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|
| Immediately after the recruiting |
| Magnetic Resonance Imaging measurement (work package 1, 2, and 3) | Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected | 1 month after the recruiting |
| Magnetic Resonance Imaging measurement (work package 1, 2, and 3) | Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected | 2 months after the recruiting |
| Magnetic Resonance Imaging measurement (work package 1, 2, and 3) | Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected | 4 months after the recruiting |
| Magnetic Resonance Imaging measurement (work package 1, 2, and 3) | Magnetic Resonance Imaging will be conducted using a 3 Tesla scanner. Specifically, T1-weighted Magnetic Resonance Imaging measure will be collected | 6 months after the recruiting |
Muscle strength will be measured in the patients by using the Medical Research Council Score
| 1 month after the recruiting |
| Muscle strength measurement (work package 3) | Muscle strength will be measured in the patients by using the Medical Research Council Score | 2 months after the recruiting |
| Muscle strength measurement (work package 3) | Muscle strength will be measured in the patients by using the Medical Research Council Score | 4 months after the recruiting |
| Muscle strength measurement (work package 3) | Muscle strength will be measured in the patients by using the Medical Research Council Score | 6 months after the recruiting |
| Sensorimotor impairment measurement (work package 3) | Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index | Immediately after the recruiting |
| Sensorimotor impairment measurement (work package 3) | Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index | 1 month after the recruiting |
| Sensorimotor impairment measurement (work package 3) | Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index | 2 months after the recruiting |
| Sensorimotor impairment measurement (work package 3) | Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index | 4 months after the recruiting |
| Sensorimotor impairment measurement (work package 3) | Sensorimotor impairment will be measured in the patients by using the Upper Extremity Fugl-Meyer index | 6 months after the recruiting |
| Spasticity measurement (work package 3) | Spasticity will be measured in the patients by using the Modified Ashworth Score | Immediately after the recruiting |
| Spasticity measurement (work package 3) | Spasticity will be measured in the patients by using the Modified Ashworth Score | 1 month after the recruiting |
| Spasticity measurement (work package 3) | Spasticity will be measured in the patients by using the Modified Ashworth Score | 2 months after the recruiting |
| Spasticity measurement (work package 3) | Spasticity will be measured in the patients by using the Modified Ashworth Score | 4 months after the recruiting |
| Spasticity measurement (work package 3) | Spasticity will be measured in the patients by using the Modified Ashworth Score | 6 months after the recruiting |
| Funtional skills measurement (work package 3). | Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing. | Immediately after the recruiting |
| Funtional skills measurement (work package 3). | Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing. | 1 month after the recruiting |
| Funtional skills measurement (work package 3). | Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing. | 2 months after the recruiting |
| Funtional skills measurement (work package 3). | Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing. | 4 months after the recruiting |
| Funtional skills measurement (work package 3). | Functional skills will be measured in the patients by using the Functional Independence Measure index. Six domains of function are evaluated: self-care, sphincter control, transfers, locomotion, communication, and social cognition. Self-care activities include dressing, eating, grooming, and bathing. | 6 months after the recruiting |
| Activities of daily living measurement (work package 3) | Activities of daily living will be measured in the patients by the Barthel Index | Immediately after the recruiting |
| Activities of daily living measurement (work package 3) | Activities of daily living will be measured in the patients by the Barthel Index | 1 month after the recruiting |
| Activities of daily living measurement (work package 3) | Activities of daily living will be measured in the patients by the Barthel Index | 2 months after the recruiting |
| Activities of daily living measurement (work package 3) | Activities of daily living will be measured in the patients by the Barthel Index | 4 months after the recruiting |
| Activities of daily living measurement (work package 3) | Activities of daily living will be measured in the patients by the Barthel Index | 6 months after the recruiting |
| Pain measurement (work package 3) | Pain level will be measured in the patients by the Visual Analog Scale for Pain | Immediately after the recruiting |
| Pain measurement (work package 3) | Pain level will be measured in the patients by the Visual Analog Scale for Pain | 1 month after the recruiting |
| Pain measurement (work package 3) | Pain level will be measured in the patients by the Visual Analog Scale for Pain | 2 months after the recruiting |
| Pain measurement (work package 3) | Pain level will be measured in the patients by the Visual Analog Scale for Pain | 4 months after the recruiting |
| Pain measurement (work package 3) | Pain level will be measured in the patients by the Visual Analog Scale for Pain | 6 months after the recruiting |
| Cognitive performance measurements (work package 3) | Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen | Immediately after the recruiting |
| Cognitive performance measurements (work package 3) | Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen | 1 month after the recruiting |
| Cognitive performance measurements (work package 3) | Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen | 2 months after the recruiting |
| Cognitive performance measurements (work package 3) | Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen | 4 months after the recruiting |
| Cognitive performance measurements (work package 3) | Cognitive functions will be measured in the patients by using the Oxford Cognitive Screen | 6 months after the recruiting |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |