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Stroke remains the leading cause of permanent disability. The neuromodulation technique of transcranial Direct Current Stimulation (tDCS) has the potential to serve as an adjuvant therapy to enhance neuronal connectivity following stroke. By combining electroencephalography (EEG) and tDCS, this study aims to investigate changes in network connectivity and cerebral plasticity, which are key factors in functional recovery after stroke.
The objectives are to: 1) analyze how tDCS modulates neuronal activity, 2) evaluate persistent effects in follow-up assessments, and 3) predict patient outcomes. Studies on human subjects will be complemented by research in a mouse model of stroke to: 1) identify the molecular mechanisms underlying tDCS effects on functional recovery, 2) establish correlations among functional, molecular, and connectivity indices, and 3) assess the efficacy of biomimetic nanoparticles in targeting injured brain tissue to reduce inflammation, enhance neuronal plasticity, and support functional recovery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS+standard rehabilitation | Experimental |
| |
| tDCS sham+standard rehabilitation | Sham Comparator |
| |
| standard rehabilitation | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Other | Transcranial direct current stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate effects of tDCS in short-term follow-ups in terms of EEG Coherence | Analysis of Magnitude Squared Coherence to evaluate short-term tDCS effects | from month 8 to month 12 |
| Evaluate persistent effect of tDCS in long-term follow-ups of EEG Coherence | Analysis of Magnitude Squared Coherence evaluate long-term tDCS effects | From month 15 to the end of project |
| Evaluate effects of tDCS in short-term follow-ups in terms of EEG Connectivity | Analysis of EEG Connectivity to evaluate short-term tDCS effects | from month 8 to month 12 |
| Evaluate persistent effect of tDCS in long-term follow-ups of EEG Connectivity | Analysis of EEG Connectivity to evaluate long-term tDCS effects | From month 15 to the end of project |
| Predict patients' outcome | Use of AI to predict the outcome of the patient | through study completion, an average of 1 year |
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Inclusion Criteria:
Age 18-90
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Casa di cura San Raffaele Pisana | Rome | Rome | 00163 | Italy |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |