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| ID | Type | Description | Link |
|---|---|---|---|
| K08DA049905 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD.
The investigators implemented a multi-site hospital-based opioid use disorder (OUD) treatment intervention across 12 hospitals in Colorado to address an OUD treatment gap among hospitalized adults with OUD. The intervention included nurse driven universal screening for unhealthy substance use with a social work referral for a brief intervention when indicted, electronic health record-embedded protocols to assess for opioid withdrawal and to direct buprenorphine initiation, methadone orders for opioid withdrawal symptoms, and embedded links for post discharge addiction treatment referral. It also included clinician education and nursing education via video conference or in-person lectures. The intervention was supported by the health system Chief Medical Officer and involved subject matters expertise and representation from nursing leaders, social work leaders, and hospital medicine leaders. Outcomes assess include a pre/post implementation assessment of 1) change in buprenorphine prescribed in hospital and 2) discharge, 3) change in naloxone prescribed, 4) change in hospital based methadone prescribing, and 5) change in average clinical opioid withdrawal scale (COWS) score. investigators also assessed a pre/post survey of hospitalists physicians and advanced practice providers to assess their perception of hospital based OUD treatment provision.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OUD intervention | Experimental | Participants received education on the diagnosis and management of OUD, have access to protocols to walk them through assessment of OUD using Diagnostic and Statistical Manual, fifth Edition (DSM)-5, COWS score to calculate severity of opioid withdrawal, buprenorphine or methadone initiation with pre-populated orders, and clickable links for OUD treatment referral post discharge. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OUD treatment intervention | Behavioral | Participants received education on the diagnosis and management of OUD, have access to protocols to walk them through assessment of OUD using Diagnostic and Statistical Manual, fifth Edition (DSM)-5, COWS score to calculate severity of opioid withdrawal, buprenorphine or methadone initiation with pre-populated orders, and clickable links for OUD treatment referral post discharge. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in buprenorphine prescribing at hospital discharge | Change in rate of buprenorphine prescribing at hospital discharge among patients with OUD before and after intervention implementation | Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change |
| Measure | Description | Time Frame |
|---|---|---|
| Change in rates of methadone prescribing during hospitalization | Change in rate of in hospital methadone prescribing among patients with OUD before and after intervention implementation | Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change |
| Measure | Description | Time Frame |
|---|---|---|
| Change in average (mean) COWS score over time | Change in rate of in mean COWS score among patients with OUD before and after intervention implementation | Calculate mean monthly COWS scores over a three year time frame (including pre and post implementation) to assess for change |
| Change in naloxone prescribing at hospital discharge |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susan L Calcaterra, MD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medicl Campus | Aurora | Colorado | 80045 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40866748 | Result | Calcaterra SL, Lockhart S, Natvig C, Mikulich-Gilbertson SK. Measuring the Impact of a Multi-Site In-Hospital Intervention for Opioid Use Disorder Treatment Provision: A Survey of Hospital-Based Clinicians. J Gen Intern Med. 2026 Mar;41(4):1048-1057. doi: 10.1007/s11606-025-09728-8. Epub 2025 Aug 27. | |
| 41715987 | Result | Calcaterra SL, Lockhart S, Grimm E, Holtrop JS, Keniston A, Hoppe JA, Lebin JA, Binswanger IA. A mixed methods assessment of an electronic health record-embedded intervention with supportive education and outreach to increase in-hospital opioid use disorder treatment initiation. J Hosp Med. 2026 Feb 19. doi: 10.1002/jhm.70289. Online ahead of print. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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This intervention will be implemented across 12 hospitals
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Change in rate of naloxone prescribing at hospital discharge among patients with OUD before and after intervention implementation |
| Calculate monthly prescribing rates over a three year time frame (including pre and post implementation) to assess for change |
| 37608527 | Result | Calcaterra SL, Lockhart S, Natvig C, Mikulich S. Barriers to initiate buprenorphine and methadone for opioid use disorder treatment with postdischarge treatment linkage. J Hosp Med. 2023 Oct;18(10):896-907. doi: 10.1002/jhm.13193. Epub 2023 Aug 22. |