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one of the most common complications associated with spinal anesthesia is hypotension, which can have adverse effects on both the mother and the fetus. The present study compare prilocaine versus bupivacaine in spinal anesthesia on hypotension and there effect on maternal outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group B | Active Comparator | Patients will be given spinal anesthesia with bupivacaine (10 mg) added to morphine (100 microgram) and will be diluted with 0.9% saline to the 3 ml final volume to be injected. |
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| Group P | Active Comparator | Patients will be given spinal anesthesia with prilocaine (50 mg) added to morphine (100 microgram) and will be diluted with 0.9% saline to the 3 ml final volume to be injected. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | Spinal anesthesia with standard dose of bupivacaine |
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| Measure | Description | Time Frame |
|---|---|---|
| Maternal arterial blood pressure | Noninvasive blood pressure will be measured at selected time frame.. Hypotension will be defined as a decrease of systolic blood pressure of at least 20% from baseline. Upon its occurrence, and/or appearance of nausea and dizziness, treatment will be immediately with ephedrine 5mg/ dose | at base line before induction and every 3 minute during the first 15 min after spinal then every 5 mins until the end of surgery and every 1 hour postoperatively for 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of duration of motor block | the time to motor block regression (duration of motor block), defined as the time between complete block (score 1) after induction of prilocaine or bupivacaine and no motor block (score 6) on the Modified Bromage scale (1, complete motor block; 2, almost complete motor block, ability to move the feet only; 3, ability to move the knees; 4, ability to raise the leg but unable to keep it raised; 5, ability to keep the leg raised for 10 s; 6, no weakness). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed G Ahmed, MD | Lecturer in anesthesiology, intensive care and pain management, South Valley University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Valley University | Qina | Egypt |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D011318 | Prilocaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Prilocaine | Drug | Spinal anesthesia with 50 mg dose of Prilocaine. |
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| will be assessed before skin incision and every 15 min intervals until the end of surgery and then at 30-min intervals until its complete regression |
| Total dose of ephedrine | When hypotension occurred postspinal ephedrine 5mg per dose will be given to restore blood pressure to 90% of its baseline value. | From beginning of administration of spinal anesthesia until complete regression of motor blockade |
| D000588 |
| Amines |