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The aim of the present study is to determine the effect of Iso-alpha-Acids and Xanthohumol from hops on the immune response of healthy participants over a timeframe of 6 hours.
In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants followed by blood draws 1, 2, 3, 4 and 6 hours after the consumption of the study drink. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical parameters, blood lipids, blood glucose, uric acid and inflammatory markers will be determined. Furthermore, blood cells, isolated from blood samples of each time point, will be stimulated for measuring inflammatory markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Xanthohumol | Experimental | Participants receive a study drink supplemented with Xanthohumol (0mg = Placebo; 0,125 mg; 0,375 mg or 0,75 mg soluble Xanthohumol) |
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| Iso-alpha-Acids | Experimental | Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo; 15 mg, 45 mg or 90 mg Iso-alpha-Acids) |
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| Xanthohumol/Iso-alpha-Acids | Experimental | Participants receive a study drink supplemented with Xanthohumol + Iso-alpha-Acids (0 mg = Placebo; 0,125 mg + 15 mg, 0,375 mg + 45 mg or 0,75 mg + 90 mg soluble Xanthohumol + Iso-alpha-Acids) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Xanthohumol | Dietary Supplement | Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo, 0,125 mg, 0,375 mg or 0,75 mg soluble Xanthohumol) |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in parameters of immune response | Changes in concentration of interleukin 6 (ng/ml) in cell culture supernatant of stimulated cells. | 6 hours |
| Changes in parameters of immune response | Changes in concentration of interleukin 1 beta (ng/ml) in cell culture supernatant of stimulated cells. | 6 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ina Bergheim, Prof. Dr. | Contact | +43-1-4277-54981 | ina.bergheim@univie.ac.at |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vienna | Recruiting | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| C104536 | xanthohumol |
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| Iso-alpha-Acids | Dietary Supplement | Participants receive a study drink supplemented with Iso-alpha-Acids (0 mg = Placebo, 15 mg, 45 mg or 90 mg Iso-alpha-Acids) |
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| Xanthohumol + Iso-alpha-Acids | Dietary Supplement | Participants receive a study drink supplemented with Xanthohumol + Iso-alpha-Acids (0 mg = Placebo, 0,125 mg + 15 mg , 0,375 mg + 45 mg or 0,75 mg + 90 mg soluble Xanthohumol + Iso-alpha-Acids) |
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