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Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intraoperative neuroelectrophysiological monitoring | Other | The procedure involves intraoperative neuroelectrophysiological monitoring. The aim is to record the electrical activity of the central and peripheral nervous system at several levels during a neurosurgical procedure. The equipment used comes from INOMED and consists of :
Electrode placement and recording take place in the operating room while the patient is under general anaesthetic (intubated and sedated). |
| Measure | Description | Time Frame |
|---|---|---|
| variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery | variation in the mean spectral power of the neuronal signal between the brain, spinal cord, roots/radicles and muscles (simultaneous recording levels) before and after surgery. Recordings are expressed as currents, themselves defined by waves. Calculating the average spectral power of the neuronal signal at several points is equivalent to quantifying the power of similarity (frequency and amplitude) between two waves. | Day 0 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with a diagnosis of spasticity requiring selective rhizotomy in neurosurgery.
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| Name | Affiliation | Role |
|---|---|---|
| Pia VAYSSIERE, MD | HFAR | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hpu Lenval | Recruiting | Nice | 06200 | France |
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| ID | Term |
|---|---|
| D009128 | Muscle Spasticity |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009122 | Muscle Hypertonia |
| D020879 | Neuromuscular Manifestations |
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| HFAR | Recruiting | Paris | 75019 | France |
|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |