Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.
To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3Tesla MRI with DTI-MRI and rsfcMRI | Other | Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia | Procedure | 2 post-operative MRI's at 2 months and 12 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR). | Baseline and 12 months |
| Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR). | Baseline and 12 months |
| Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR) | Baseline and 12 months |
| Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences | This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR) | Baseline and 12 months |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manish N Shah, MD | Contact | 713 500-7410 | Manish.N.Shah@uth.tmc.edu | |
| Bangning L Yu, RN, PhD | Contact | 713 500-7363 | Bangning.Yu@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Manish N Shah, MD | UTHealth Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UTHealth & Children's Memorial Hermann Hospital | Recruiting | Houston | Texas | 77030 | United States |
Not provided
| ID | Term |
|---|---|
| D002547 | Cerebral Palsy |
| ID | Term |
|---|---|
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D056324 | Diffusion Tensor Imaging |
| ID | Term |
|---|---|
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| D038524 |
| Diffusion Magnetic Resonance Imaging |
| D008279 | Magnetic Resonance Imaging |
| D014054 | Tomography |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |