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In order to clarify the clinical efficacy of electroacupuncture on inhibiting systemic inflammatory response, improving respiratory mechanics parameters and prognosis in patients with sepsis-related ARDS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | Experimental group: Sterile stainless steel needle electroacupuncture treatment was applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days. |
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| Control group | No Intervention | Control group: Placebo needles were applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acupuncture needles | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory mechanics indicators 1 | Oxygenation index(P/F) | Day 0、day 7 |
| Respiratory mechanics indicators 2 | Respiratory rate(RR) | Day 0、day 7 |
| Respiratory mechanics indicators 3 | Driving pressure(DP) | Day 0、day 7 |
| Respiratory mechanics indicators 4 | Positive end expiratory pressure(PEEP) | Day 0、day 7 |
| Respiratory mechanics indicators 5 | Mechanical ventilation days(MV days) | Day 0、day 7 |
| Respiratory mechanics indicators 6 | Mechanical ventilation free days(MV free days) | Day 0、day 7 |
| Respiratory mechanics indicators 7 | Extubation situation | Day 0、day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Sedation and analgesia | RASS score | Day 0、day 7 |
| Sedative drug use | The dose and duration of sedative medication will be recorded. | Day 0、day 7 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jun Lu, Doctor | Contact | +86 13813865758 | lujun@njucm.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jun Lu, Doctor | Jiangsu Province Hospital of Traditional Chinese Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine | Nanjing | Jiangsu | 210029 | China |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D007239 | Infections |
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|
| Analgesic drug use | The dose and duration of analgesic medication will be recorded. | Day 0、day 7 |
| Inflammatory factors | IL-1β、IL-6、IL-2、IL-4、IL-5、IL-8、IL-10、IL-17、IL-12、 IFN-γ、IFN-α、TNF-α. | Day 0、day 7 |
| CD4、CD8、CD4/CD8 | Flow cytometry will be used to detect serum CD4, CD8 and CD4/CD8 levels. | Day 0、day 7 |
| Vasoactive drugs applications | The duration of vasoactive drug use will be recorded. | Day 0 to day 7 |
| CRRT applications | The duration of continuous renal replacement therapy will be recorded. | Day 0 to day 7 |
| ECMO applications | The duration of extracorporeal membrane oxygenation will be recorded. | Day 0 to day 7 |
| All-cause mortality to day 28 | The prognosis of patients on the 28th days will be counted. | Up to 28 days |
| All-cause mortality to day 60 | The prognosis of patients on the 60th days will be counted. | Up to 60 days |
| ICU-free days | The prognosis of patients ICU length of stay will be counted. | 2 year |
| Hospital-free days | The prognosis of patients total length of stay will be counted. | 2 year |
| D018746 |
| Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |