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To investigate the effect of electroacupuncture on patients with sepsis-associated brain injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| electroacupuncture | Experimental | The investigators choose Zusanli (ST36) and Baihui (DU20) acupoints to investigate the effect of electroacupuncture on patients with sepsis-associated brain injury. |
|
| shame electroacupuncture | Sham Comparator | The shame electroacupuncture were performed at a shallow depth and 1 mm lateral to Zusanli (ST36) and Baihui (DU20) acupoints. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electroacupuncture | Other | The patients in Group EA received electroacupuncture at Zusanli (ST36) (located 5 mm below the head of the inferior fibula and 2 mm lateral to the anterior tibial tuberosity) and Baihui (DU20) (located in the midpoint of the parietal bone) acupoints, the stainless steel acupuncture needles were connected to a Hans acupoint nerve stimulator and inserted into the acupoints. |
| Measure | Description | Time Frame |
|---|---|---|
| neuron specific enolase,NSE | Serum index of sepsis-associated brain injury. | Change of NSE from Baseline at 7 days |
| sTREM2 | Serum index of sepsis-associated brain injury. | Change of sTREM2 from Baseline at 7 days |
| soluble protein-100β,S100β | Serum index of sepsis-associated brain injury. | Change of S100β from Baseline at 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Acute Physiology and Chronic Health Evaluation，APACHE II | To assess the severity of the disease. | Change of APACHE II from Baseline at 7 days |
| Glasgow Coma Scale，GCS | To assess the degree of coma. |
| Measure | Description | Time Frame |
|---|---|---|
| length of stay in hospital | 2 months | |
| fatality rate at 28 days after discharge | 2 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jianbo Yu, MD | Contact | 86-22-27435873 | yujianbo11@126.com | |
| Jianbo Yu, MD | Contact | 022-27435873 | yujianbo11@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Nankai Hospital | Recruiting | Tianjin | Tianjin Municipality | 300000 | China |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D015671 | Electroacupuncture |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D015670 | Acupuncture Therapy |
| D000529 | Complementary Therapies |
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|
| shame electroacupuncture | Other | The patients in Group SEA received electroacupuncture at a shallow depth and 1 mm lateral to Zusanli (ST36) (located 5 mm below the head of the inferior fibula and 2 mm lateral to the anterior tibial tuberosity) and Baihui (DU20) (located in the midpoint of the parietal bone) acupoints, the stainless steel acupuncture needles were connected to a Hans acupoint nerve stimulator and inserted into the acupoints. |
|
| Change of GCS from Baseline at 7 days |
| Montreal Cognitive Assessment (MoCA) scale | Rapid screening for cognitive function abnormalities。 | Change of MoCA from Baseline at 7 days |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D004599 |
| Electric Stimulation Therapy |
| D026741 | Physical Therapy Modalities |
| D012046 | Rehabilitation |
| D004561 | Transcutaneous Electric Nerve Stimulation |
| D000698 | Analgesia |
| D000760 | Anesthesia and Analgesia |
| D000758 | Anesthesia |