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There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.
Knee osteoarthritis is one of most frequent reason of knee pain. There are different treatment methods such as analgesic drug treatment, physical therapy techniques, intraarticular injections and neurolysis techniques. In this study, we will compare neurolysis techniques these are phenol block and corticosteroid local anesthetic block.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phenol block group | Experimental |
| |
| Corticosteroid and local anesthetic | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenol | Drug | Chemical neurolysis |
| |
| Celestone |
| Measure | Description | Time Frame |
|---|---|---|
| Numeric Rating Scale (NRS) | Average knee pain is assessed using an 11-point NRS with terminal descriptors of no pain (score 0) and extreme pain (score 10). | Before the intervention, 4 weeks after the intervention and 3 months later |
| Measure | Description | Time Frame |
|---|---|---|
| Western Ontario and McMaster Universities Arthritis Index (WOMAC) | We will use the WOMAC in the Likert version where question are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. So the sum of the scores ranges from 0 (the best) to 96 (the worse). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rabia Layık | Contact | +905314087679 | rabialyk@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gaziler | Recruiting | Ankara | Çankaya | Turkey (Türkiye) |
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| Drug |
Chemical neurolysis with corticosteroid |
|
| Lidocain | Drug | Chemical neurolysis with local anesthetic |
|
| Before the intervention, 4 weeks after the intervention and 3 months later |
| Patient Global Impression of Change (PGIC) | The PGIC in pain and function will be measured with a 5-point Likert scale (1-5) on the applicable follow up visits. The patients will be asked to rate the following statements: Please imagine how you would have described your pain intensity before the procedure. How do you feel today as compared to baseline (Start of the study) as far as your knee pain caused by OA is concerned? Please imagine how you would have described the functionality of your knee before the procedure. How do you feel today as compared to baseline (start of the study) as far as your knee functionality caused by OA is concerned? The options on the Likert scale are: much better slightly better no change slightly worse much worse | 4 weeks after the intervention and 3 months later |
| Sixt Minute Walk Test (6MWT) | A 6 minute walk test is a submaximal exercise test that measures the distance walked over the span of 6 minutes. | Before the intervention, 4 weeks after the intervention and 3 months later |
| The Timed-Up and Go test | This test measures the dynamic balance and functional mobility in older adults.A patient getting up from a chair from the sitting to the bipedal position, walking three meters, turning, returning, and sitting on the chair again. | Before the intervention, 4 weeks after the intervention and 3 months later |
| Frequency of analgesic usage | Assessment of analgesic number that used by patient with knee osteoarthritis | Before the intervention, 4 weeks after the intervention and 3 months later |
| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D019800 | Phenol |
| D001623 | Betamethasone |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
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