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The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score.
The participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| genicular nerve phenol neurolysis | Experimental | chemical neurolysis using 2 mL of 9% phenol solution prepared from crystallized phenol will be applied to each genicular nerve. |
|
| genicular nerve radiofrequency ablation | Experimental | Radiofrequency thermocoagulation will be applied to each nerve at 80 degrees for 90 seconds. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genicular nerve neurolysis | Procedure | The superior medial genicular nerve (SMGN), superior lateral genicular nerve (SLGN), and inferior medial genicular nerve (IMGN) will be blocked either by phenol neurolysis or radiofrequency ablation |
| Measure | Description | Time Frame |
|---|---|---|
| Numeric rating scale | By an independent physician pain will be recorded using numeric rating scale which is a screening tool used to assess pain severity using a 0 - 10 scale with zero meaning no pain and 10 meaning the worst pain ever. | baseline, 2, 4, 8,12 and 16 weeks after the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| oxford knee score | This score is used to assess both function and pain of the knee on a scale ranging from 0 (worst pain and function) and 48 (best function and no pain) this score will be recorded by an independent physician | baseline, 4, 8, 12, 16 weeks after the procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ahmed boeith, MD | Contact | 02001003074795 | ahmedabdelrahamn2008@med.asu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed Boeith, MD | Ain Shams University | Principal Investigator |
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| ID | Term |
|---|---|
| D018771 | Arthralgia |
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D012216 | Rheumatic Diseases |