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This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sufentanil group | Experimental | sufentanil is administered for analgesic during general anesthesia |
|
| remifentanil group | Active Comparator | remifentanil is administered for analgesic during general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sufentanil | Drug | Induction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| opioid consumption | During post-anesthesia care unit(PACU) stay, until 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Richmond Agitation-Sedation scale | (+4), Combative, Overtly combative or violent; immediate danger to staff (+3), Very agitated, Pulls on or removes tube(s) or catheter(s) or has aggressive behavior toward staff (+2), Agitated, Frequent nonpurposeful movement or patient-ventilator dyssynchrony (+1), Restless, Anxious or apprehensive but movements not aggressive or vigorous 0, Alert and calm, Spontaneously pays attention to caregiver (-1), Drowsy, Not fully alert, but has sustained (more than 10 seconds) awakening, with eye contact, to voice (-2), Light sedation, Briefly (less than 10 seconds) awakens with eye contact to voice (-3), Moderate sedation, Any movement (but no eye contact) to voice (-4), Deep sedation, No response to voice, but any movement to physical stimulation (-5), Unarousable, No response to voice or physical stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chang-Hoon Koo | Contact | +821085098841 | vollock9@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Chang-Hoon Koo | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam | South Korea |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D017409 | Sufentanil |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Remifentanil | Drug | Induction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml |
|
| During post-anesthesia care unit(PACU) stay, until 1 hour |
| Incidence of postoperative nausea and vomiting | During post-anesthesia care unit(PACU) stay, until 1 hour |
| Number of patients who administered antiemetics | ramosetron will be administered as antiemetics | During post-anesthesia care unit(PACU) stay, until 1 hour |
| Pain score | Numeric rating scale (0=none, 10=extremely pain) | immediately after surgery, 15minutes, 30minutes, 60minutes after surgery |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D011422 |
| Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |