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This study is a multi-center, observational, real-world study for patients with resected lung cancers in China. With the help of a properly designed data processing algorithm and extensively performed data quality assurance, this study aims to harness the potential of real-world big data to (1) describe characteristics and treatment patterns and their evolving trends; (2) discover features associated with overall survival; and (3) address recently-emerging clinical questions.
Lung cancer is the leading cause of cancer-related deaths in China. The recent decade witnessed rapid evolving of demographics, pathological features and prognoses of patients with surgically resected lung cancers. The introduction of minimally invasive surgery (MIS) concept and techniques, targeted therapy and immunotherapy changed treatment landscape for patients with surgically resected lung cancers. With more early-stage lung cancers discovered due to the application of CT screening, questions focusing on extent of lung resection, lymph node dissection, application of targeted or immune-therapy to early-stage lung cancers are emerging. This study aims to create a cohort of patients with surgically resected lung cancers and an analytic framework to address the aforementioned clinical questions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with surgically resected lung cancer | Patients who were diagnosed with lung cancer and received surgical resection in participating medical centers during the designed study period. |
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| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Time from surgery to death from any cause. | January 2014 to December 2031 |
| Measure | Description | Time Frame |
|---|---|---|
| Baseline characteristics of included participants | Demographics, symptoms at diagnosis, tobacco exposure, family history, previous medical history, etc. | January 2014 to December 2028 |
| Treatment patterns of included participants |
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Inclusion Criteria:
Exclusion Criteria:
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Participants eligible for this study would be screened from consecutive patients who received surgical resection for lung malignancies in participating medical centers during the designed study period.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fengwei Tan, MD-PhD | Contact | +8601087787792 | tanfengwei@126.com | |
| Renda Li, MD | Contact | lirenda@cicams.ac.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jie He, MD-PhD | National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, CAMS and PUMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | Recruiting | Beijing | Beijing Municipality | 100021 | China |
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Extent of lung resection and lymph node dissection, application of certain surgical techniques or not; application of chemotherapy, targeted therapy, immunotherapy and/or radiotherapy before and/or after surgery.
| January 2014 to December 2028 |
| Pathological characteristics of included participants | Location, size, classification, presence or absence of certain pathological features of resected tumor(s); number of metastasized and dissected lymph nodes in each station. | January 2014 to December 2028 |
| Features associated with overall survival | Features within the range of collected baseline characteristics, treatment patterns and pathological characteristics that are associated with overall survival. | First analysis is anticipated to be performed from April to August 2024; the final analysis is anticipated in 2032. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D000077192 | Adenocarcinoma of Lung |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| D055752 | Small Cell Lung Carcinoma |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
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