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The objective is to evaluate the effects on the skin of 3 foods supplements compared to placebo after daily intake for 3 months in female subjects presenting healthy skin.
Skin parameters measured are: the firmness of the skin and other biomechanical skin properties (elasticity, tonicity, density), cellulitis visibility, radiance complexion, skin condition (microrelief, skin barrier function and moisturizing)
Study design: Monocentric, randomized, double blind, placebo controlled, 3 groups in parallel.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Maltodextrin |
|
| Verum1 | Experimental | Combination of clove (Syzygium aromaticum) and immortelle (Helichrysum italicum) extracts |
|
| Verum2 | Experimental | Olive fruit extract (Olea europaea) |
|
| Verum3 | Experimental | Hibiscus flower extract (Hibiscus sabdariffa) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Botanicals extracts | Dietary Supplement | Powder included in capsules for daily administration |
|
| Measure | Description | Time Frame |
|---|---|---|
| Firmness of the skin | Cutometry measurements using Cutometer (cheekbone) | Day 0 (inclusion) and Day 84 (last visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Skin elasticity and tonicity | Cutometry measurements using the Cutometer (cheekbone) | Day 0 (inclusion) and Day 84 (last visit) |
| Skin density | Ultrasound imaging device (lower cheek) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Intertek | Paris | 75013 | France |
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| Placebo | Dietary Supplement | Maltodextrin included in capsules for daily administration |
|
| Day 0 (inclusion) and Day 84 (last visit) |
| Score of fine lines visibility on face, assessed by panelist (trained technician) | 10 points numeric scale: 0 (not visible) to 9 (highly visible) | Day 0 (inclusion) and Day 84 (last visit) |
| Score of skin radiance of face, assessed by panelist (trained technician) | 10 points numeric scale: 0 (dull) to 9 (radiant) | Day 0 (inclusion) and Day 84 (last visit) |
| Score of nourishing aspect (hydration and quality aspect) of face, assessed by panelist (trained technician) | 10 points numeric scale: 0 (malnourished) to 9 (nourished) | Day 0 (inclusion) and Day 84 (last visit) |
| Score of skin firmness (tactile pinch of right cheek), assessed by panelist (trained technician) | 10 points numeric scale: 0 (sagging) to 9 (firm) | Day 0 (inclusion) and Day 84 (last visit) |
| Score of skin softness (tactile perception of right cheek), assessed by panelist (trained technician) | 10 points numeric scale: 0 (rough) to 9 (soft) | Day 0 (inclusion) and Day 84 (last visit) |
| Score of cellulite visibility (right thigh), assessed by panelist (trained technician) | 10 points numeric scale: 0 (not visible) to 9 (highly visible) | Day 0 (inclusion) and Day 84 (last visit) |
| Dimpled skin - volume (mm3) of humps and dimples | Picture acquisition by fringe projection (on tight) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Dimpled skin - surface (mm2) of humps and dimples | Picture acquisition by fringe projection (on tight) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Skin luminosity - CIELAB (L*a*b) | Standardized pictures acquisitions (face) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Skin color texture - Haralick parameter (contrast & entropy - no unit) | Standardized pictures acquisitions (face) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Skin specular reflectance (spectral reflectance - no unit) | Standardized pictures acquisitions (face) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Skin roughness (mean height - µm) | Standardized 3D pictures acquisitions (cheek) and software integration | Day 0 (inclusion) and Day 84 (last visit) |
| Skin barrier function (g/h/m²) | Trans-epidermal water loss (forearm) | Day 0 (inclusion) and Day 84 (last visit) |
| Skin moisture (%) | Reflected electromagnetic probe (forearm) | Day 0 (inclusion) and Day 84 (last visit) |
| Self perceived questionnaire (4 scales) | Questionnaire (Satisfied, Somewhat satisfied, Somewhat unsatisfied, Unsatisfied) | Day 0 (inclusion), Day 42 (intermediate) and Day 84 (last visit) |