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Carotenoids and polyphenols are assumed to have an active role in skin health. Sources for these phytonutrient are fruits and vegetables. They are widely applied as skin protectants, and supplementation with carotenoids have shown to protect against erythema caused by UV-radiation. UV radiation generates reactive oxygen species in the skin, which induces cellular signaling that may impair cell cycle, cell growth, and regeneration or repair processes.
The face holds an integral role in human social communication and how humans are perceived as attractive. In addition to structural facial features, studies have shown that skin appearance is highly weighed in the perception of beauty and is determined primarily by its coloration and surface topography. Aging is caused by two processes, intrinsic and extrinsic. The sun is the primary cause of extrinsic aging and has also been shown to alter the normal course of intrinsic or natural aging. On the molecular level, various hypotheses have been proposed to explain aging, with free radical theory being prominent. The free radical theory addresses the concept of intrinsic biological instability of living systems, in which free radicals and other reactive oxygen species (ROS) damage biomolecules, and this damage results in aging of the skin (as well as other systems).
The aim of this study is to examine the effects of an oral antioxidant supplement on skin aging and skin condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lycoderm | Experimental | soft gel contains nutritional supplement |
|
| Placebo | Placebo Comparator | Soft gel without active ingredients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lycoderm | Dietary Supplement | soft gel contains nutritional supplement |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Improves skin hydration | instrumental evaluation (Corneometer) | 16 weeks |
| Improves skin smoothness and texture | image analysis (Antera) | 16 weeks |
| Improves lines and wrinkles | image analysis (Clarity) | 16 weeks |
| Improves skin barrier function | instrumental evaluation (VapoMeter) | 16 weeks |
| Improves skin thickness and density | instrumental evaluation (DermaScan Ultrasound) | 16 weeks |
| Increases dermal hemoglobin | instrumental evaluation (SIAScope). | 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
17. Woman known to be pregnant, lactating or planning to become pregnant within six months. Subjects who become pregnant during the study must inform the Principal Investigator immediately and will be excluded from the study.
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| Name | Affiliation | Role |
|---|---|---|
| Robert Frumento, Phd | IRSI | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| International Research Services, Inc. | Port Chester | New York | 10573 | United States |
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Double Blind, Randomized, Placebo-Controlled
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Double Blind, Randomized
| Placebo |
| Dietary Supplement |
soft gel without active ingredients |
|