Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
the research highlight the effectiveness of probiotics as adjuncts to SRP in the treatment of periodontitis stage III grade C molar-incisor pattern
Background data : Periodontitis is a common disease that represents a public health problem. Aggregatibacter actinomycetemcomitans (A. a ) especially the JP2 genotype plays a major role in the pathogenesis of periodontitis. The aim of this study is to evaluate the effect of topically applied probiotics on the management of periodontitis stage III grade C molar-incisor pattern.
Methods: Sixty-five patients having periodontitis stage III grade C molar-incisor pattern. Screening for A. actinomycetemcomians (A.a) and the JP2 genotype was done using conventional polymerase chain reaction (PCR). Patients positive for (A. a) were randomly divided into two groups. Group I: received conventional periodontal treatment combined with topically applied probiotic, while Group II: received conventional periodontal treatment only. Both groups were evaluated microbiologically and clinically. Quantitative assessment of A. a levels was done by real time PCR (qPCR) at baseline as well as one week, 4 weeks, and 12 weeks after treatment. Clinical parameters were assessed before treatment as well as 3,6 and 9 months after treatment.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group probiotic | Active Comparator | received conventional periodontal treatment combined with topically applied probiotic |
|
| Group placebo | Placebo Comparator | received conventional periodontal treatment only. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotic Formula | Drug | intra-pocket formula (local delivery drug) |
|
| Measure | Description | Time Frame |
|---|---|---|
| quantitative assessment of A. actinomycetemcomians levels by picogram | Microbiological evaluation by picogram | at baseline (before treatment) used by conventional PCR |
| Assessment of clinical periodontal parameter : Probing pocket Depth (PPD) by mm | Clinical evaluation mm | at base line , 1 , 3 , 6 months |
| Assessment of clinical periodontal parameter : Clinical Attachment Level (CAL) by mm | Clinical evaluation by "mm" | at base line , 1 , 3 , 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| quantitative assessment of A. actinomycetemcomians levels by picogram | microbiological by picogram | baseline ,1 ,3 and 6 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ibrahim H Ibrahim, Ass.prof. | Al-Azhar University | Principal Investigator |
| Mohamed A EL-Mokhtar, Prof | Assiut University | Study Director |
| Mohamed F Edrees, prof. | Al-Azhar University | Principal Investigator |
| Heba A Hammad, Ass.prof | Assiut University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alazhar university ,faculty of Dental Medicine | Asyut | 0000 | Egypt |
Not provided
| Label | URL |
|---|---|
| Orchid | View source |
| National library of Medicine | View source |
| web of science |
Not provided
Effect of probiotics on periodontitis stage III grade C molar-incisor pattern
1 month
DOI: 10.21203/rs.3.rs-3837892/v1
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 19, 2026 | |
| Reset | Feb 4, 2026 | |
| Release | Mar 7, 2026 | |
| Reset | Mar 26, 2026 |
Not provided
Not provided
| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 19, 2026 | Feb 4, 2026 | |||
| Mar 7, 2026 |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
Not provided
Not provided
Sixty-five patients having periodontitis stage III grade C molar-incisor pattern. Screening for A. actinomycetemcomians (A.a) and the JP2 genotype was done using conventional polymerase chain reaction (PCR). Patients positive for (A. a) were randomly divided into two groups. Group I: received conventional periodontal treatment combined with topically applied probiotic, while Group II: received conventional periodontal treatment only. Both groups were evaluated microbiologically and clinically.
Not provided
Not provided
Not provided
Not provided
| placebo formula | Drug | intra-pocket formula (local delivery drug) |
|
|
| Mar 26, 2026 |