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The goal of this observational study is to learn about serum and urine metabolome in patients after cardiac surgery.
The main objective of this study is to collect blood and urine samples from patients after cardiac surgery, and to perform metabolomic analysis to find the differential metabolites and their enrichment pathways in AKI patients and non-AKI patients.The secondary objective is to intervene in its enrichment pathway to find ways to improve CSA-AKI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AKI group | AKI is then defined as an increase in serum creatinine (SCr) of at least 26.4 μmol/L over 48 hours, or an increase in SCr greater than 1.5 times baseline over 7 days, or a urine output of less than 0.5 mL/kg per hour for more than 6 hours, according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. | ||
| Non-AKI group | According to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, patients do not develop acute kidney injury. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other |
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| Measure | Description | Time Frame |
|---|---|---|
| serum and urine metabolome studies | The preoperative and postoperative metabolomic differences in blood and urine between AKI group and non-AKI group were compared. | January 2025 - December 2025 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with cardiac surgery who have undergone cardiopulmonary bypass. Acute kidney injury is defined according to the KIDIGO guidelines.
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| Name | Affiliation | Role |
|---|---|---|
| Chen Wenxiu | Nanjing First Hospital, Nanjing Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing First Hospital | Nanjing | China |
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The serum sample was obtained by collecting blood samples with a serum separation hose containing serum procoagulant, allowing it to coagulate after standing at room temperature for 60min, centrifuging at 3000rmb at 4 °C for 10 min, aspirating the supernatant (i.e., serum 200ul) and dividing it into a suitable numbered 2ml centrifuge tube, liquid nitrogen quick-freezing for 5-10 min, and storage in a -80 °C freezer to avoid repeated freezing and thawing. Urine specimen collection is to use urine in a urine bag, centrifuge at 10000rmb at 4 °C for 10min, aspirate 500ul of supernatant in a numbered 2ml sterile centrifuge tube, liquid nitrogen quick-freeze for 5-10min, and store in a freezer at -80 °C to avoid repeated freezing and thawing.