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In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient. Pain management after total knee arthroplasty TKA is an important consideration to improve patient outcomes and reduce length of stay. Periarticular injections of the knee are one of the techniques used to reduce pain after surgery. Studies have shown that compared to other methods of pain relief, they are effective and safe. At present, no studies to compare between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection in Simultaneous Bilateral TKA patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multimodal Intraosseous Femoral Injection | Experimental | Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in femoral canal |
|
| Multimodal Intraosseous Tibial Injection | Experimental | Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in tibial canal |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multimodal Intraosseous Femoral Injection | Drug | Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in femoral canal |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain score (Visual analog scale) | Visual analog scale (VAS) score from 0-10(0 was no pain, 10 was worst pain ) between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection | at 12 hours, 24 hours, 48 hours and 2 weeks after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Amount of painkillers used | up to 24 hours after surgery | |
| Post operative blood loss | intraoperative and up to 48 hours postoperatively (include intraoperative and drain) | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thakrit Chompoosang, MD | Contact | +66846461916 | tk_ortho@hotmail.com | |
| Tanahem Wijit, MD | Contact | +66956855458 | troy.erdos@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Thakrit Chompoosang, MD | Department of Medical Services Ministry of Public Health of Thailand | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rajavithi hospital | Recruiting | Phaya Thai | Bangkok | 10400 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35272897 | Background | Brozovich AA, Incavo SJ, Lambert BS, Sullivan TC, Wininger AE, Clyburn TA, Taraballi F, Park KJ. Intraosseous Morphine Decreases Postoperative Pain and Pain Medication Use in Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial. J Arthroplasty. 2022 Jun;37(6S):S139-S146. doi: 10.1016/j.arth.2021.10.009. Epub 2022 Mar 7. | |
| 25922311 |
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| Multimodal Intraosseous Tibial Injection | Drug | Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in tibial canal |
|
| Knee and Osteoarthritis Outcome Score (KOOS) |
minimum and maximum values(0-100), higher scores mean a better outcome. |
| post operative 2 weeks |
| knee range of motion | post operative 2 weeks |
| Side effects and complications | intraoperative to post operative 2weeks |
| Length of hospital stay | Length of hospital stay record in number of days | Admit to discharge date (up to 7 days) |
| Fan L, Zhu C, Zan P, Yu X, Liu J, Sun Q, Li G. The Comparison of Local Infiltration Analgesia with Peripheral Nerve Block following Total Knee Arthroplasty (TKA): A Systematic Review with Meta-Analysis. J Arthroplasty. 2015 Sep;30(9):1664-71. doi: 10.1016/j.arth.2015.04.006. Epub 2015 Apr 8. |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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