Comparison of Outcomes Between Intraosseous Femoral and Tibial Injection in Simultaneous Bilateral Total Knee Arthroplasty Patients

Comparison of Outcomes Between Multimodal Intraosseous Femoral Injection and Multimodal Intraosseous Tibial Injection, a Randomized Controlled Trial in Simultaneous Bilateral Total Knee Arthroplasty Patients

In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient. Pain management after total knee arthroplasty TKA is an important consideration to improve patient outcomes and reduce length of stay. Periarticular injections of the knee are one of the techniques used to reduce pain after surgery. Studies have shown that compared to other methods of pain relief, they are effective and safe. At present, no studies to compare between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection in Simultaneous Bilateral TKA patients.

Inclusion Criteria:

• Patients who will undergo bilateral Total knee Replacement due to osteoarthritis of both knees
• Used of a cemented, PS design TKA surgery.
• Able to give informed consent

Exclusion Criteria:

• Revision TKA
• History of previous knee or hip surgery
• History of allergic reaction or side effects to the drug that will be used in the experiment
• Underlying diseases of chronic kidney disease or chronic liver disease (Child Pugh B or C)
• Pregnancy
• History of coagulopathy or abnormal blood coagulation profile(INR >1.4 or aPTT ratio > 1.4)
• History of platelet dysfunction or platelet count < 140,0000/mm3
• History of Thromboembolism
• Use of Anticoagulants.