We are group of researchers interested in causes and management of nocturnal enuresis, we embarked on this research on 2020 and we reached promising results regarding the role of vitamin D serum level in etiology and management of monosymptomatic enuresis.

this research was conducted as a comparative study regarding serum vitamin D levels in monosymptomatic enuretic and non enuretic children, also we compared urine osmolality and nocturnal polyuria in both groups and we found that low vitamin D levels are correlated with low nocturnal urine osmolality and increased incidence of nocturnal polyuria

Inclusion Criteria:

• Patients with PMNE.
• which was defined as bedwetting frequency of 3 or more nights per week for at least 2 weeks of observation.
• Didn't receive any previous treatment for enuresis.

Exclusion Criteria:

• Patients with non-monosymptomatic enuresis (associated with storage and/or voiding symptoms). -Patients with anatomical abnormalities (Meatal stenosis, Hypospadias, Epispadias, etc.).
• Patients with neurological diseases.
• Patients with Renal impairment.
• Patient with previous pelvic, urological or brain and spinal cord surgery.
• Patients with chronic constipation and irritable bowel habits.
• Patients with active urinary tract infection.
• Patients who are on vitamin D supplements.

male and female children from 5-15 years wer selcted in two groups 60 enuretic children 60 non enuretic children as a control group