The Effect of Melatonin on Nocturnal Enuresis

The Effect of Melatonin on Nocturnal Enuresis

Aim: To investigate the effect of melatonin in bedwetting.

Design: Double blind randomized placebocontrolled trial using crossover.

Inclusion Criteria:

• Monosymptomatic nocturnal enuresis
• Age 6-14 years
• Clinical examination normal
• ≥ 3 wet nights / week due to either nocturnal polyuria with normal bladder size or reduced functional bladder capacity with normal urine output

Exclusion Criteria:

• Constipation (by ROME III criteria)
• Day incontinence
• Overactive bladder (ICCS 2008 classification of symptoms)
• Current or past history of clinical or laboratory findings that can be related to diseases or - conditions (eg pregnancy) likely to change the parameters examined, especially diseases of the kidney and urinary tract, liver or endocrine disorder.
• Clinical signs of urinary tract infection
• Hypertension, blood pressure assessed by ambulatory measurement with blood pressure cuff
• Set treatment with one or more drugs