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The results of ketamine, ketamine and midazolom and placebo can be copied after birth in cesareans subjected to spinal anesthesia.
Postpartum depression will be evaluated by dividing the patients into 3 groups: group 1 as ketamine, group 2 as ketamine and midasom, and group 3 as placebo group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Grup 1 -Ketamine Group | Ketamine Group (GROUP 1) 0.5 mg/kg IV single dose bolus diluted to 5 ml with 0.9% saline |
| |
| Group 2-ketamine + midazolam | Midazolam 0.0125 mg/kg is given followed by a single IV bolus dose of 0.5 mg/kg diluted to 5 ml with 0.9% saline. |
| |
| Group 3-placebo | Group 3-placebo ;A single dose of IV 5 ml physiological saline will be given. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia | Drug | A single dose of 0.5 mg/kg IV diluted to 5 ml with 0.9% saline was planned to be administered simultaneously to the Ketamine Group (GROUP 1), ketamine and midazolam within 5 minutes after the newborn umbilical cord was clamped (Group 2). After midazolam 0.03 mg/kg is given, a single dose IV bolus of 0.5 mg/kg diluted to 5 ml with 0.9% saline will be administered. Patients experience dizziness, hallucinations, nausea, headache, vomiting, diplopia and blurred vision, the time until the first analgesic request; Depression parameters will be evaluated with the Edinburgh Postpartum Depression Scale (EPDS) in all patients before cesarean section and at the 1st, 2nd and 4th weeks after birth. |
| Measure | Description | Time Frame |
|---|---|---|
| postpartum depression | Reducing postpartum depression with low-dose ketamine | 4 weeks |
| intraoperative complications | Reducing postpartum depression by reducing ketamine-related intraoperative complications | 1 day |
| postoperative pain | Reducing postoperative pain with low dose ketamine | 1 day |
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Inclusion Criteria:
American Society of Anesthesiologists 2-.3 18 -45years old Patients planned to be born by cesarean section The patient requests a cesarean section with spinal anesthesia
ExclusionCriteria:
Pathological obstetric complications
Hypertension
Contraindication for ketamine Contraindication for spinal
being a patient undergoing cesarean section
Patients undergoing cesarean section under spinal anesthesia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| DUYGU DEMIROZ, dr | Contact | +905319504421 | drduygudemiroz@hotmail.com | |
| OSMAN TOPLU, dr | Contact | 905321137771 | osman.toplu@inonu.edu.tr |
| Name | Affiliation | Role |
|---|---|---|
| DUYGU DEMIROZ | Inonu University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inonu universitesi | Malatya | 44050 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D019052 | Depression, Postpartum |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008874 | Midazolam |
| ID | Term |
|---|---|
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D011644 | Puerperal Disorders |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D006571 | Heterocyclic Compounds |