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In this retrospective study from professor Kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry. Insulin resistance was calculated using laboratory data
This was an analytical cross-sectional retrospective study involving patients with suspected CAD who underwent coronary angiography between December 2018 and May 2023. The information was obtained from patients referred to the outpatient cardiovascular clinic (Professor Kojuri Cardiology Clinic, Shiraz, Iran, www.kojuriclinic.com). Data was extracted from Professor Kojuri Cardiology Clinic database, including patient's information about the clinical history, presence or absence of specific diseases, angiography/angioplasty results, medications, and laboratory values.
A total of 14,708 patients who had undergone coronary angiography at least once were examined. After applying exclusion criteria, 1017 eligible cases were selected for data analysis.
The following data was recorded for the included patients: demographic data, past medical history (such as DM, hypertension, etc.), systolic and diastolic blood pressure, weight and height, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and serum creatinine (Cr). Body mass index (BMI) was calculated as weight (Kg) divided by the square of height (m2). Obesity was defined as BMI ≥ 30 Kg/m2.
Laboratory values were selected from the time before angiography, and if not available, from the time shortly after the angiography. This helped us find those values which could best represent the metabolic state of patients at the time of angiography, while reducing the confounding effect of statin use.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| coronary artery disease | patients with coronary angiography of at least one vessel with more than 50% stenosis |
| |
| no coronary artery disease | patient with no stenosis in coronary angiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| triglyceride to glucose ratio | Diagnostic Test | Ratio of triglyceride level to glucose |
|
| Measure | Description | Time Frame |
|---|---|---|
| insulin resistance index: level of triglyceride to glucose ratio from blood sample | correlation of coronary artery disease and triglyceride glucose ratio in blood laboratory tests | 3 years |
| insulin resistance index: Level of triglyceride to HDL ratio from blood sample | correlation of coronary artery disease and triglyceride to HDL level ratio in blood laboratory sample | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| metabolic syndrome | metabolic syndrome based on criteria of metabolic syndrome | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients more than 18 years old referred for evaluation of coronary artery disease for their first time
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| Name | Affiliation | Role |
|---|---|---|
| Javad Kojuri, MD. MS. | Professor kojuri cardiology clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shiraz University of Medical Sciences | Shiraz | Fars | 7134814336 | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40401209 | Derived | Jahangiri S, Mosalamiaghili SA, Heydarzadeh R, Yousefzadeh M, Golchin Vafa R, Zarifkar H, Assadian K, Sohrabizadeh S, Zarifkar H, Sadeghi M, Hosseini N, Montaseri M, Hosseini SA, Kojuri J. Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study. ARYA Atheroscler. 2025;21(1):44-53. doi: 10.48305/arya.2025.42573.2960. |
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Data are available based on rational request
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| triglycerdie to HDL ratio | Diagnostic Test | Ratio of triglyceride to HDL cholesterol |
|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |