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The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is:
• Is handgrip strength correlated with small airway disease in COPD patients? Participants will perform handgrip strength test and impulse oscillometry (IOS).
This is a cross-sectional study in COPD patients. COPD patients aged 40 years or older were included. Handgrip strength test and impulse oscillometry will be tested in each patient. Handgrip strength will be measured using a hand dynamometer. Small airway disease will be assessed using IOS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD | COPD patients aged 40 years or older with a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) <0.7. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Handgrip strength | Diagnostic Test | Handgrip strength will be measured by 3 efforts. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between handgrip strength and small airway disease in COPD patients | This correlation will be reported as correlation coefficient (R). | At day 1 of the study |
| Measure | Description | Time Frame |
|---|---|---|
| The best cutoff value of handgrip strength for predicting small airway disease in COPD patients | The best cutoff value will be determined by the area under the Receiver Operator Characteristic curve (ROC). | At day1 of the study |
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Inclusion Criteria:
Exclusion Criteria:
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COPD patients aged 40 years or older who are confirmed diagnosis by spirometry (post-bronchodilator FEV1/FVC <0.7) and smoking history 10 pack-years or more.
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| Name | Affiliation | Role |
|---|---|---|
| Narongkorn Saiphoklang, MD | Thammasat University Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thammasat University Faculty of Medicine | Pathum Thani | Changwat Pathum Thani | 12120 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39367749 | Derived | Keawon T, Saiphoklang N. Association between handgrip strength and small airway disease in patients with stable chronic obstructive pulmonary disease. Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241281675. doi: 10.1177/17534666241281675. |
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Individual participant data (IPD) and documents will be available for sharing immediately after publication for a period of 2 years.
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |