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Obesity and lack of exercise are one of the reasons for high blood pressure. Exercise can reduce the risk of cardiovascular events by reducing weight and blood pressure. The precise formulation of exercise prescription by cardiopulmonary exercise test (CPET) can effectively control hypertension. Our research group has formulated 50 "exercise prescriptions for hypertension population" in the early stage, but how to further effectively implement them needs to be discussed.
Based on the previous experience of undertaking the project "Exercise Prescription for Hypertensive People" of General Administration of Sport of the People's Republic of China, this research group discussed the important role of intelligent information management in the clinical effect evaluation and effective implementation of exercise prescription for hypertension; To explore the feasibility of making exercise prescription for hypertension based on 6-min walking test, and whether it is not inferior to or equivalent to the accuracy and effectiveness of making exercise prescription by CPET. The relevant results will lay a foundation for exploring the broader adaptation of hypertension exercise prescription to the population.
The 6-minute walking test (6MWT) has good universality and accessibility, and can be used as the basis for formulating exercise prescriptions. According to the consensus of Chinese experts on the application of clinical norms of the six-minute walking test, it is recommended to formulate individualized exercise prescriptions based on the average walking speed of 6MWT calculated from the six-minute walking distance (6MWD), but there is no relevant content about hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPET exercise prescription group | Experimental | Formulate exercise prescription of cardiopulmonary exercise test (CPET) according to the principle of FITT [frequency, intensity, time and type] |
|
| 6MWT exercise prescription group | Experimental | Exercise prescription is set according to the recommendation of the Chinese expert consensus on the application of clinical norms of six-minute walking test |
|
| Regular exercise group | Active Comparator | Carry out regular exercise as usual |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CPET exercise prescription | Behavioral | Exercise mode: walk Frequency: 5 times/week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure, SBP | systolic blood pressure (mmHg) | through study completion, an average of 1 year |
| Diastolic blood pressure, DBP | diastolic blood pressure (mmHg) | through study completion, an average of 1 year |
| Heart rate, HR | Heart rate (beats/min) | through study completion, an average of 1 year |
| Pulse wave velocity, PWV | pulse wave velocity | through study completion, an average of 1 year |
| PWV | pulse wave velocity | through study completion, an average of 1 year |
| weight | weight (kg) | through study completion, an average of 1 year |
| Body mass index, BMI | body mass index （kg/m^2） | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Blood lipids | Triglyceride, total cholesterol, low-density lipoprotein cholesterol | through study completion, an average of 1 year |
| exercise hypertension | yes/no |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Xi, Doctor | Contact | +86-10-88325552 | yangxi1016@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Yang Xi, Doctor | Peking University People's Hospital | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32860412 | Background | Pelliccia A, Sharma S, Gati S, Back M, Borjesson M, Caselli S, Collet JP, Corrado D, Drezner JA, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli MF, Prescott E, Roos-Hesselink JW, Graham Stuart A, Taylor RS, Thompson PD, Tiberi M, Vanhees L, Wilhelm M; ESC Scientific Document Group. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021 Jan 1;42(1):17-96. doi: 10.1093/eurheartj/ehaa605. No abstract available. |
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To protect the privacy of patients in the maximum extent
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| 6MWT exercise prescription | Behavioral | Exercise mode: walk Frequency: 5 times/week |
|
| Regular exercise | Behavioral | Regular exercise |
|
| through study completion, an average of 1 year |
| circadian rhythm of blood pressure | Ambulatory blood pressure monitoring | through study completion, an average of 1 year |
| anxiety | Anxiety score using Generalized Anxiety Disorder (GAD-7). High GAD-7 scores significantly predicted worse state of anxiety: no anxiety,0-4 scores; mild anxiety,5-9 scores; moderate anxiety,10-14 scores; severe anxiety,15-21 scores. | through study completion, an average of 1 year |
| depression | Depression score using Patient Health Questionnaire-9 (PHQ-9). High PHQ-9 scores significantly predicted worse state of depression: no depression,0-4 scores; mild depression,5-9 scores; moderate depression,10-14 scores; severe depression,15-27 scores. | through study completion, an average of 1 year |
| use of antihypertensive drugs | Record dosage and numbers of antihypertensive drugs using questionnaires. | through study completion, an average of 1 year |