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Dentin sensitivity is one of the most common problems in society and affects the quality of life related to oral health. Agents such as toothpaste, mouthwash, and dental cream are home-type desensitizing agents used as the first step in the treatment of dentin hypersensitivity. A total of 180 individuals with dentin sensitivity will be included in the study and the individuals will be randomly divided into 6 groups. Individuals in the 1st Group will be given arginine-containing toothpaste, individuals in the 2nd Group will be given novamin-containing toothpaste, individuals in the 3rd Group will be given propolis-containing toothpaste, individuals in the 4th Group will be given casein phosphopeptide amorphous calcium phosphate-containing dental cream, and individuals in the 5th Group will be given mouthwash containing potassium nitrate. Classic toothpaste with 1450 ppm fluoride will be distributed to individuals in the control group, which is the 6th group. The Dentin Hypersensitivity Experience Questionnaire (DHEQ-15), consisting of 15 questions, will be used to evaluate dentin sensitivity. Visual Analogue Scale (VAS) will be used to determine the individual's pain score in dentin sensitivity, and the individual will be asked to score the intensity of pain experienced between 0-10 points. Finally, in the evaluation of dentin sensitivity, a single dentist will apply air to the cervix of the tooth from a distance of 1 cm for 1 second, and the Schiff Sensitivity Scale score will be determined through clinical examination. A score between 0 and 3 will be determined by the dentist according to the patient's response to the air stimulus. The effectiveness of the home-use desensitizing agents used in the treatment of dentin hypersensitivity was evaluated with DHEQ-15, VAS and Schiff Sensitivity Scale; Baseline, 4th and 8th week scores will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Active Comparator | 1450 ppm fluoride toothpaste |
|
| Arginine | Active Comparator | toothpaste containing arginine |
|
| Novamin | Active Comparator | toothpaste containing novamin |
|
| Propolis | Active Comparator | toothpaste containing propolis |
|
| Casein Phosphopeptide Amorphous Calcium Phosphate | Active Comparator | Dental cream containing casein phosphopeptide amorphous calcium phosphate |
|
| Potassium Nitrate | Active Comparator | mouthwash containing potassium nitrate |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control group | Other | Brushing teeth twice a day for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dentine Hypersensitivity Experience Questionnaire-15 (DHEQ-15) | Dentin Hypersensitivity Experience Questionnaire-15 (DHEQ-15) is a 7-point Likert scale form consisting of 15 questions used to evaluate dentin sensitivity, with answers ranging from 'strongly agree' to 'strongly disagree'. | for 8 weeks (initially, 4 weeks and 8 weeks) |
| Visual Analogue Scale (VAS) | VAS is a scale in which the individual evaluates the pain level between 0 (no hurt) and 10 (hurts worst). | for 8 weeks (initially, 4 weeks and 8 weeks) |
| Schiff Sensitivity Scale | In the evaluation of dentin hypersensitivity, a single dentist will apply air to the cervix of the tooth from a distance of 1 cm for 1 second during a clinical examination and the Schiff Sensitivity Scale score will be determined. 0: subject does not respond to air stimulus
| for 8 weeks (initially, 4 weeks and 8 weeks) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Canakkale Onsekiz Mart University Faculty of Dentistry | Çanakkale | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31640741 | Background | Mason S, Burnett GR, Patel N, Patil A, Maclure R. Impact of toothpaste on oral health-related quality of life in people with dentine hypersensitivity. BMC Oral Health. 2019 Oct 22;19(1):226. doi: 10.1186/s12903-019-0919-x. | |
| 24117696 | Background | Baker SR, Gibson BJ, Sufi F, Barlow A, Robinson PG. The Dentine Hypersensitivity Experience Questionnaire: a longitudinal validation study. J Clin Periodontol. 2014 Jan;41(1):52-9. doi: 10.1111/jcpe.12181. Epub 2013 Nov 6. |
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| ID | Term |
|---|---|
| D003807 | Dentin Sensitivity |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| D001120 | Arginine |
| C510984 | NovaMin |
| D011429 | Propolis |
| C447032 | casein phosphopeptide-amorphous calcium phosphate nanocomplex |
| C023844 | potassium nitrate |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| Arginine | Other | Brushing teeth twice a day for 8 weeks |
|
| Novamin | Other | Brushing teeth twice a day for 8 weeks |
|
| Propolis | Other | Brushing teeth twice a day for 8 weeks |
|
| Casein Phosphopeptide Amorphous Calcium Phosphate | Other | Following the procedure in the control group, it is applied to the tooth surface once a day for 3 minutes before going to bed at night for 8 weeks |
|
| Potassium Nitrate | Other | Following the procedure in the control group, mouthwash twice a day in the morning and evening for 8 weeks |
|
| 29369544 | Background | Basaran S, Celik C. Turkish Adaptation of Dentine Hypersensitivity Experience Questionnaire (DHEQ). Community Dent Health. 2018 Mar 1;35(1):47-51. doi: 10.1922/CDH_4151Basaran05. |
| 39810073 | Derived | Ayan G, Msmall i, Ukrainianssmall i, Ukrainianllsmall i, Ukrainian T, Buldur M. Home-use agents in the treatment of dentin hypersensitivity: clinical effectiveness evaluation with different measurement methods. Clin Oral Investig. 2025 Jan 15;29(1):63. doi: 10.1007/s00784-025-06155-1. |
| D008722 | Methods |
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
| D000601 | Amino Acids, Essential |
| D012116 | Resins, Plant |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D053147 | Plant Exudates |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |