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Dentin hypersensitivity is a common problem in society. Untreated hypersensitivity affects the patient's quality of life, complicates plaque control and increases the risk of caries and periodontal disease. This study aimed to evaluate the clinical efficacy of desensitizing toothpastes containing sodium fluoride, stannous fluoride, nano-hydroxyapatite, 8% arginine and calcium carbonate.
Fourty eight patients with at least two teeth with positive responses to air and mechanical stimulus were included in the study and were divided into four groups. Sodium fluoride (Colgate®, Cavity Protection) in group A, stannous fluoride (Oral B® Gum Calm & Sensitivity) in group B, nano-hydroxyapatite (ApaCare®) in group C and 8% arginine and calcium carbonate combination in group D (Colgate® Sensitive Pro- ReliefTM) were used by the patients continuously for 16 weeks. Dentin hypersensitivity, by using VAS and Shiff scores and periodontal parameters were evaluated at baseline, 2nd week, 4th week and last 16th week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A (Sodium Monofluorophosphate) | Active Comparator | Dentifrice containing Sodium Monofluorophosphate, daily homecare usage Colgate®, Cavity Protection |
|
| Group B (Stannous Fluoride) | Active Comparator | Dentifrice containing Stannous Fluoride, daily homecare usage Oral B®, Gum Calm & Sensitivity |
|
| Group C (Nano-Hydroxyapatite) | Active Comparator | Dentifrice containing Nano-Hydroxyapatite, daily homecare usage ApaCare® |
|
| Group D (8% Arginine & Calcium Carbonate) | Active Comparator | Dentifrice containing 8% Arginine & Calcium Carbonate, daily homecare usage Colgate®, Sensitive Pro-Relief |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sodium Monofluorophosphate | Other | Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Hypersensitivity Reduction | Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be'). | Baseline, 2nd week, 4th week, 16th week |
| Hypersensitivity Reduction | The Schiff Scale examiner covers the adjacent teeth on either side of the patient's hypersensitive tooth with his/her fingers. Air from the tip of the dental unit's air-water sprayer is applied to the cervical region of the hypersensitive tooth at a distance of approximately 1 cm for 1 second. The degree of hypersensitivity is scored according to the Schiff cold air sensitivity scale. Scoring : Score 0: The individual does not respond to the stimulus. Score 1: The individual responds to the stimulus but does not request its termination. Score 2: The individual responds to the stimulus and requests its termination or moves to avoid the stimulus. Score 3: The individual responds to the stimulus, finds the stimulus painful and requests its termination. The pain persists for a few seconds after the stimulus is terminated. | Baseline, 2nd week, 4th week, 16th week |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Periodontal Measurements | Probing depths (mm) | Baseline, 16th week |
| Clinical Periodontal Measurements | Clinical attachment levels (mm) |
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Inclusion Criteria:
Exclusion Criteria:
People who have;
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| Name | Affiliation | Role |
|---|---|---|
| İlknur ÖZENCİ | Altinbas University | Study Chair |
| Şebnem DİRİKAN İPÇİ | Altinbas University | Study Director |
| Gökser ÇAKAR | Altinbas University | Study Director |
| Sevdenur GÜNENÇ | Altinbas University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Altinbas University | Istanbul | 34147 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D003807 | Dentin Sensitivity |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| C012980 | fluorophosphate |
| D014002 | Tin Fluorides |
| C509317 | nano-hydroxyapatite-collagen |
| D001120 | Arginine |
| D002119 | Calcium Carbonate |
| ID | Term |
|---|---|
| D005459 | Fluorides |
| D006858 | Hydrofluoric Acid |
| D017611 | Fluorine Compounds |
| D007287 | Inorganic Chemicals |
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|
| Stannous Fluoride | Other | Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks. |
|
| Nano-Hydroxyapatite | Other | Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks. |
|
| 8% Arginine & Calcium Carbonate | Other | Test toothpaste, participants will brush selected sensitive teeth each for 30 seconds followed by the whole mouth thoroughly for at least one minute. The method of application of these agents will be the fingertip method. Patients continued to use the paste twice daily, morning and evening, for 16 weeks. |
|
| Baseline, 16th week |
| Clinical Periodontal Measurements | Plaque score (%), | Baseline, 16th week |
| Clinical Periodontal Measurements | Bleeding score (%) | Baseline, 16th week |
| D017971 |
| Tin Compounds |
| D002327 | Cariostatic Agents |
| D001697 | Biomedical and Dental Materials |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
| D000601 | Amino Acids, Essential |
| D017610 | Calcium Compounds |
| D002254 | Carbonates |
| D002255 | Carbonic Acid |
| D017554 | Carbon Compounds, Inorganic |
| D008903 | Minerals |