ctDNA and MRI Parameters in Head and Neck Cancer

ctDNA and MR Imaging Parameters as Possible Biomarkers in Primary Radiochemotherapy of Head and Neck Squamous Cell Carcinomas

Patients undergoing primary radiochhemotherapy for locally advanced head and neck squamous cell carcinomas are included in this study. In addition to standard of care treatment patients will undergo addiational blood draws and MR imaging studies. Circulating cell free tumor DNA will be analysed in the blood samples. BIological data, imaging data and clinical data (such as patient and tumor characteristics, oncologic outcome, side effects) will be analysed in a biomathematical modelling approach.

Inclusion Criteria:

• Squamous cell carcinoma head and neck
• Planned primary platinum based radiochemotherapy
• ECOG 0-2

Exclusion Criteria:

• Palliative therapy intent
• Not MR eligible