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observation of IDH1 and OCT4 markers level and high grade astrocytoma patients prognosis after excision.
explore the relationship between prognosis and IDH1 and OCT4 biomarkers after high grade astrocytoma excision , according to progression free survival and overall survival , in prospective and retrospective samples.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biomarkers analysis | Other | IDH1 and OCT4 markers analysis of surgical specimens of high grade astrocytoma |
| Measure | Description | Time Frame |
|---|---|---|
| IDH1 and OCT4 markers and their relation to postoperative prognosis of high grade astrocytoma patients | explore the relationship between prognosis (progression free and overall survival ) and biomarkers (IDH1 and OCT4 ) after excision of high grade astrocytoma | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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patients with high grade astrocytic glioma , more than 18 years old and fit for surgery that will be admitted in the department of neurosurgery in Assiut university hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdelrahman A Salama, resident | Contact | 01002796190 | adhamsalama001@gmail.com | |
| Mahmoud H Ragab, professor | Contact | 01004001789 | Ragabm@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine of Assiut University | Recruiting | Asyut | 71525 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | PubMed | ||
| 24842956 | Result | Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087. | |
| 26948349 |
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| ID | Term |
|---|---|
| D001254 | Astrocytoma |
| ID | Term |
|---|---|
| D005910 | Glioma |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
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| Result |
| Perry A, Wesseling P. Histologic classification of gliomas. Handb Clin Neurol. 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. |
| 17964028 | Result | Sathornsumetee S, Rich JN, Reardon DA. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov;25(4):1111-39, x. doi: 10.1016/j.ncl.2007.07.004. |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |