Prospective randomized controlled clinical trials (single arm study) of surgical treatment modalities for supratentorial high grade gliomas within the next two years.

Supratentorial high grade gliomas are for surgical resection in any case according to many factors.

Investigators will compare the outcomes/survival rate and clinical outcome of the different resection types (Total, near total, subtotal/debulking) of supratentorial high grade gliomas according to the clinical condition and comorbidities of the patient, the location and morphology of the lesion, the grading of lesions, and the clinical experience of the neurosurgeon.

Inclusion Criteria:

• Patients who will undergo surgical excision of the supratentorial high grade gliomas at the time of study (two years).
• Denovo disease for the first time.
• Any age

Exclusion Criteria:

• Low-grade Gliomas.
• Infratentorial high-grade gliomas.
• Past history of gliomas.
• Patients who are unfit for any neurosurgical interventions.
• Patients who do not receive their adjuvant standard therapy.

All cases of patients of supratentorial high grade gliomas that fullfill the selection criteria that will be admitted in the department of neurosurgery in Assuit university hospital. (Non propability sample size) with expected size of 28 patients starting from 01/07/2019 to 15/06/2021.

Patients whose follow-ups will be lost due to any other cause will be excluded from this study (expected to be 25%). Additionally, the competence of follow-up will be approved by imaging and medical records.