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| Name | Class |
|---|---|
| Andalusian School of Public Health | OTHER_GOV |
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This study aimed to assess the effectiveness of a comprehensive, multicomponent intervention utilizing education and support for Benzodiazepines withdrawal compared to standard care.
The excessive use of benzodiazepines (BZDs) presents significant health concerns and high healthcare costs, particularly in Spain, where usage rates are among the highest globally. In Andalusian, over a 10% of the population use BZDs long-term, prompting the need for safe and effective reduction strategies.
This study aimed to assess the effectiveness of a comprehensive, multicomponent intervention utilizing education and support for BZD withdrawal compared to standard care.
The intervention involved educational discussions, consultations with health professionals, and letters supported by multiple scientific societies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention for reducing benzodiazepines long-term use. | Experimental | It included the multiple components as follows: (i) an exchange discussion with the patient describing the advantages, disadvantages and alternatives of benzodiazepines use and a tapering protocol with the support of educational material, (ii) the offer of a brief, if necessary, consultation with the family doctor, and (iii) a letter addressed to the patient supported by scientific societies. |
|
| Usual Care | No Intervention | Usual Care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention for reducing benzodiazepines long-term use. | Behavioral | Comprehensive, multicomponent intervention utilizing education and support for benzodiazepines. Family doctor, nurse, community pharmacist and social workers: carried out informative discussion with the patient with by providing educational material. They informed patients about the advantages, disadvantages and alternatives to benzodiazepines including a descending benzodiazepines schedule to minimize withdrawal symptoms. It briefly explained the professionals' concerns about the continued use of benzodiazepines and offers possible solutions. If the patient requested a withdrawal, he/she was referred to the doctor. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of dispensing of benzodiazepines. | Number of dispensing of benzodiazepines, measured at the level of the participant. | 3.5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Knowledge | Knowledge: Empower questionary, measured at the level of the participant. | 6 months |
| Life Quality | Quality of life:Functional Status Measurement Sheets by coop World Organisation of Family Doctors (COOP/ WONCA): The six COOP-WONCA Charts are described by vignettes and measured at the level of the participant: physical fitness, feelings, daily activities, social activities, change in health and overall health. WONCA: World Organisation of Family Doctors |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ingrid Ferrer López, Ph.D | SAS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ingrid Ferrer López | Seville | 41011 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41703502 | Derived | Ferrer Lopez I, Spacirova Z, Olry de Labry-Lima A, Gutierrez-Valencia A, Florencio Sayago M, Martinez Celdran M, Sumariva Bernal MA, Bermudez-Tamayo C. Cost-utility analysis of benzodiazepine deprescription in primary care: a cohort study. BMC Health Serv Res. 2026 Feb 17;26(1):390. doi: 10.1186/s12913-026-14149-2. | |
| 41142506 | Derived |
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| ID | Term |
|---|---|
| D000067490 | Prescription Drug Overuse |
| ID | Term |
|---|---|
| D063487 | Prescription Drug Misuse |
| D000076064 | Drug Misuse |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D008722 | Methods |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
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cluster-randomized, parallel-group trial in which health centres were the units of randomization and patients were the units of analysis
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Data collector was not involved in outcomes assessment.
|
| 6 months |
| Ferrer Lopez I, Olry de Labry-Lima A, Gutierrez-Valencia A, Garcia Bermudez E, Atienza Martin F, Morente AG, Murillo Fernandez MD, Sanchez Canete Y, Bermudez-Tamayo C. Risk perception, attitudes, and quality of life in a multicomponent benzodiazepine deprescription strategy. Explor Res Clin Soc Pharm. 2025 Sep 30;20:100666. doi: 10.1016/j.rcsop.2025.100666. eCollection 2025 Dec. |
| D001523 | Mental Disorders |