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| Name | Class |
|---|---|
| Zorgverzekeraar CZ | OTHER |
| Scientific Institute for Dutch Pharmacists, The Netherlands | OTHER |
The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.
In Dutch community pharmacies many projects have been undertaken in the field of pharmaceutical care, with mixed results. It is not yet clear which elements exactly contribute to the success of these projects and to implementation of pharmaceutical care.
One of the subjects to which attention is paid in community pharmacies, is the undesirable long-term use of benzodiazepines. Treatment methods for discontinuation of long-term benzodiazepine use have been studied rather extensively. A simple patient-directed discontinuation letter proved to be effective in several studies.
Comparison: a minimal intervention group (pharmacists carrying out the intervention guided by a manual only) compared to a maximal intervention group (pharmacists receiving a manual, a training aimed at better cooperation and communication with family practitioners and some support in the management of the project).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| training and follow-up of pharmacists | Behavioral | |||
| patient-directed discontinuation letter | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| percentage of general practitioners that reviewed and returned the list of longterm users. | ||
| percentage of letters sent by the pharmacists in the four months after receiving the manual. | ||
| percentage of long-term benzodiazepine users that managed to quit or significantly reduce their use in months 0-3, 4-6 and 10-12 after receiving the letter. |
| Measure | Description | Time Frame |
|---|---|---|
| evaluation of the implementation strategies |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter G de Smet, PhD | Scientific Institute for Dutch Pharmacists, The Netherlands | Principal Investigator |
| Michel Wensing, PhD | Centre for Quality of Care Research Nijmegen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Apotheek Schellekens | 's-Hertogenbosch | 5212 NC | Netherlands | |||
| Apotheek Cleij |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9090699 | Background | Odedina FT, Hepler CD, Segal R, Miller D. The Pharmacists' Implementation of Pharmaceutical Care (PIPC) model. Pharm Res. 1997 Feb;14(2):135-44. doi: 10.1023/a:1012032223328. | |
| 8625021 | Background | Anderson GM, Lexchin J. Strategies for improving prescribing practice. CMAJ. 1996 Apr 1;154(7):1013-7. |
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| 's-Hertogenbosch |
| 5213 VG |
| Netherlands |
| Apotheek Empel | 's-Hertogenbosch | 5236 AC | Netherlands |
| Apotheek Asten | Asten | 5721 EZ | Netherlands |
| Apotheek Bakel-Milheeze | Bakel | 5761 BN | Netherlands |
| Kring-apotheek Bergeyk | Bergeijk | 5571 HE | Netherlands |
| Apotheek Berlicum | Berlicum | 5258 AW | Netherlands |
| Lloyds Apotheek van Kollenburg | Best | 5683 AE | Netherlands |
| Apotheek de Schakel | Best | 5684 ER | Netherlands |
| Apotheek Heivelden | Best | 5685 HS | Netherlands |
| Apotheek Blanckenburgh | Beuningen | 6641 DD | Netherlands |
| Apotheek Bladel | Bladel | 5531 CV | Netherlands |
| Apotheek Bocholtz | Bocholtz | 6351 ES | Netherlands |
| Apotheek van de Wouw | Brunssum | 6441 CD | Netherlands |
| Apotheek Budel | Budel | 6021 HT | Netherlands |
| Apotheek in 't Groen | Deurne | 5751 BG | Netherlands |
| Apotheek Koolen-Motké | Deurne | 5751 CB | Netherlands |
| Apotheek de Schelde | Deurne | 5751 VH | Netherlands |
| Apotheek Druten | Druten | 6651 DE | Netherlands |
| Apotheek de Kempen | Eersel | 5521 CA | Netherlands |
| Apotheek Elsloo | Elsloo | 6181 AS | Netherlands |
| Apotheek Ewijk | Ewijk | 6644 BR | Netherlands |
| Apotheek Eygelshoven | Eygelshoven | 6471 JH | Netherlands |
| Lloyds Apotheek Geldrop | Geldrop | 5664 GG | Netherlands |
| Apotheek het Frans Brugske | Gemert | 5421 HN | Netherlands |
| Apotheek Lindner | Gemert | 5421 KW | Netherlands |
| Apotheek de Duivenakker | Gennep | 6591 CZ | Netherlands |
| Apotheek Gennep | Gennep | 6591 CZ | Netherlands |
| Apotheek de Pijlers | Goes | 4461 LT | Netherlands |
| Zeeuwse Apotheek | Goes | 4462 DZ | Netherlands |
| Apotheek de Goese Polder | Goes | 4463 VA | Netherlands |
| Apotheek Groesbeek | Groesbeek | 6562 AH | Netherlands |
| Linde apotheek | Hapert | 5527 BN | Netherlands |
| Apotheek Heeswijk-Dinther | Heeswijk-Dinther | 5473 GB | Netherlands |
| Apotheek Tendijck | Helmond | 5701 HN | Netherlands |
| Service Apotheek de Bus | Helmond | 5702 HW | Netherlands |
| Service apotheek Vondellaan | Helmond | 5702 HW | Netherlands |
| Apotheek de Luifel | Helmond | 5703 GA | Netherlands |
| Apotheek Brouwhuis | Helmond | 5704 LK | Netherlands |
| Kring-apotheek de Rijpel | Helmond | 5709 BT | Netherlands |
| Lloyds Apotheek Herkenbosch | Herkenbosch | 6075 AG | Netherlands |
| Apotheek Hegtermans | Herten | 6049 BS | Netherlands |
| Apotheek Herten-Merum | Herten | 6049 ES | Netherlands |
| apotheek Kerkrade-centrum | Kerkrade | 6461 AL | Netherlands |
| Apotheek Schonefeld | Kerkrade | 6461 EP | Netherlands |
| Apotheek Bleijerheide | Kerkrade | 6462 AL | Netherlands |
| Apotheek Medische Centrum West Kerkrade | Kerkrade | 6466 BR | Netherlands |
| Apotheek Terwinselen | Kerkrade | 6467 GC | Netherlands |
| Apotheek Waubach | Landgraaf | 6370 JA | Netherlands |
| Apotheek Landgraaf | Landgraaf | 6371 BM | Netherlands |
| Apotheek MC Putstraat | Landgraaf | 6372 BK | Netherlands |
| Apotheek Schaesberg | Landgraaf | 6372 CN | Netherlands |
| Apotheek Nieuwenhagen | Landgraaf | 6373 KK | Netherlands |
| Apotheek Maarheeze | Maarheeze | 6026 ER | Netherlands |
| Apotheek Craveld | Maasbracht | 6050 AD | Netherlands |
| Apotheek Maasbracht | Maasbracht | 6050 AD | Netherlands |
| Service apotheek Malden | Malden | 6581 BG | Netherlands |
| Apotheek Maasdorpen | Meerlo | 5864 AG | Netherlands |
| Lloyds Apotheek de Roerstreek | Melick | 6074 AP | Netherlands |
| Apotheek Ringeling | Middelburg | 4331 AM | Netherlands |
| Apotheek Hummelen | Middelburg | 4331 LL | Netherlands |
| Apotheek Stromenwijk 't Zand | Middelburg | 4335 GT | Netherlands |
| Apotheek Welsinge | Middelburg | 4336 ED | Netherlands |
| Apotheek Dauwendaele | Middelburg | 4337 JH | Netherlands |
| Apotheek van der Ploeg | Nijmegen | 6522 CA | Netherlands |
| Kring-apotheek Beckers | Nijmegen | 6524 DL | Netherlands |
| Apotheek Souburg | Oost-Souburg | 4388 CC | Netherlands |
| Lloyds Apotheek Postert | Posterholt | 6061 EG | Netherlands |
| Apotheek Reusel | Reusel | 5541 CS | Netherlands |
| Lloyds Apotheek Clemens-Haan | Roermond | 6041 HS | Netherlands |
| Reinald apotheek | Roermond | 6041 XB | Netherlands |
| Apotheek Hendrickx-Maasniel | Roermond | 6042 JL | Netherlands |
| Lloyds Apotheek Donderberg | Roermond | 6043 JR | Netherlands |
| Apotheek Roermond Zuid | Roermond | 6045 GC | Netherlands |
| Apotheek Rosmalen-Walschot | Rosmalen | 5241 BL | Netherlands |
| Apotheek Rosmalen | Rosmalen | 5242 HT | Netherlands |
| apotheek Simpelveld-Bocholtz | Simpelveld | 6369 VP | Netherlands |
| Apotheek Hopveld | Sint-Michielsgestel | 5271 XP | Netherlands |
| Apotheek de Baandert | Sittard | 6136 KE | Netherlands |
| Wandelbos Apotheek | Tilburg | 5044 PB | Netherlands |
| Apotheek de Belleman | Valkenswaard | 5551 EW | Netherlands |
| Apotheek Valkenswaard | Valkenswaard | 5554 CA | Netherlands |
| Apotheek Vlaslant | Valkenswaard | 5554 HA | Netherlands |
| Apotheek Dommeldal | Valkenswaard | 5554 RM | Netherlands |
| apotheek 't Zuid | Veghel | 5463 CP | Netherlands |
| Veldhovense Apotheek | Veldhoven | 5503 BP | Netherlands |
| Apotheek Zonderwijk | Veldhoven | 5505 AJ | Netherlands |
| Apotheek van Poppel | Wijchen | 6601 ZX | Netherlands |
| Apotheek Dr. H. Kilian | Wijchen | 6602 DB | Netherlands |
| Apotheek Wijchen-Zuid | Wijchen | 6605 HN | Netherlands |
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| 14584231 | Background | Muijrers PE, Knottnerus JA, Sijbrandij J, Janknegt R, Grol RP. Changing relationships: attitudes and opinions of general practitioners and pharmacists regarding the role of the community pharmacist. Pharm World Sci. 2003 Oct;25(5):235-41. doi: 10.1023/a:1025872907411. |
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| 12777340 | Background | Voshaar RC, Gorgels WJ, Mol AJ, van Balkom AJ, van de Lisdonk EH, Breteler MH, van den Hoogen HJ, Zitman FG. Tapering off long-term benzodiazepine use with or without group cognitive-behavioural therapy: three-condition, randomised controlled trial. Br J Psychiatry. 2003 Jun;182:498-504. doi: 10.1192/bjp.182.6.498. |
| 12117625 | Background | Couvee JE, Timmermans MA, Zitman FG; Dutch Chronic Benzodiazepine Working Group. The long-term outcome of a benzodiazepine discontinuation programme in depressed outpatients. J Affect Disord. 2002 Jul;70(2):133-41. doi: 10.1016/s0165-0327(01)00330-5. |
| 15951127 | Background | Mol AJ, Oude Voshaar RC, Gorgels WJ, Breteler MH, van Balkom AJ, van de Lisdonk EH, Kan CC, Mulder J, Zitman FG. The absence of benzodiazepine craving in a general practice benzodiazepine discontinuation trial. Addict Behav. 2006 Feb;31(2):211-22. doi: 10.1016/j.addbeh.2005.04.024. Epub 2005 Jun 13. |
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| 15769557 | Background | Gorgels WJ, Oude Voshaar RC, Mol AJ, van de Lisdonk EH, van Balkom AJ, van den Hoogen HJ, Mulder J, Breteler MH, Zitman FG. Discontinuation of long-term benzodiazepine use by sending a letter to users in family practice: a prospective controlled intervention study. Drug Alcohol Depend. 2005 Apr 4;78(1):49-56. doi: 10.1016/j.drugalcdep.2004.09.001. |
| 11484431 | Background | Oude Voshaar RC, Gorgels WJ, Mol AJ, Couvee JE, van Balkom AJ, Zitman FG. [Treatment methods for discontinuation of long-term benzodiazepine use]. Ned Tijdschr Geneeskd. 2001 Jul 14;145(28):1347-50. Dutch. |
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| 18801626 | Derived | van de Steeg-van Gompel CH, Wensing M, De Smet PA. Implementation of a discontinuation letter to reduce long-term benzodiazepine use--a cluster randomized trial. Drug Alcohol Depend. 2009 Jan 1;99(1-3):105-14. doi: 10.1016/j.drugalcdep.2008.07.009. Epub 2008 Sep 17. |