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Participants were 44 overweight and obese persons, male and female, age 18-59 years. Participants were divided into 2 groups consisting of 23 asparagus capsules and 21 placebo capsules groups. They received health screenings including history taking, mental health questionnaire, and vital signs, height and body weight, body composition, fat distribution measurements and oral glucose tolerance test. Then, a venipuncture was conducted to determine blood glucose, insulin, lipids malondialdehyde and protein carbonyl levels.
The study design was cross-sectional. Participants were 44 overweight and obese persons, male and female, age 18-59 years. Participants were divided into 2 groups consisting of 23 asparagus capsules and 21 placebo capsules groups. They received health screenings including history taking, mental health questionnaire, and vital signs, height and body weight, body composition, fat distribution measurements and oral glucose tolerance test. Then, a venipuncture was conducted to determine blood glucose, insulin, lipids malondialdehyde and protein carbonyl levels. Analysis of covariance was used to analyze parameters between groups and paired t-test was used to analyze parameters intra-group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asparagus capsule | Experimental | Participants were randomized to receive an arm. In this arm, participants received asparagus capsule and were asked to consume at 40 mg/kg (1-2 capsule) within 15-30 min after breakfast. Consumption was taken at participants' dwelling. |
|
| Placebo capsule | Placebo Comparator | Participants were randomized to receive an arm. In this arm, participants received placebo capsule and were asked to consume at 40 mg/kg (1-2 capsule) within 15-30 min after breakfast. Consumption was taken at participants' dwelling. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Asparagus capsule | Dietary Supplement | Asparagus capsule is categorized as dietary supplement. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Level of body fat | Level of body fat was measured in percentage unit | Day 0 and end of 12 weeks |
| Level of fat mass | Level of fat mass was measured in kilogram unit | Day 0 and end of 12 weeks |
| Level of fat distribution | Level of fat distribution was measured by ratio of waist (centimeter) to hip (centimeter) | Day 0 and end of 12 weeks |
| Concentration of blood glucose | Concentration of blood glucose was measured in serum in mmol/L unit | Day 0 and end of 12 weeks |
| Concentration of blood insulin | Concentration of blood insulin was measured in serum in uU/mL (microunit/milliliter) unit | Day 0 and end of 12 weeks |
| Concentrations of blood lipids | Concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured in serum in mg/dL unit | Day 0 and end of 12 weeks |
| Concentration of blood malondialdehyde | Concentration of blood malondialdehyde was measured in plasma in uM (micromolar) unit | Day 0 and end of 12 weeks |
| Concentration of blood protein carbonyl |
| Measure | Description | Time Frame |
|---|---|---|
| Concentrations of blood glucose from oral glucose tolerance test | Concentrations of blood glucose were measured before and after glucose consumption at 75 g/100 ml in mg/dL unit | At 0 minute before glucose consumption and at 30, 60, 90, 120 minutes after glucose consumption |
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Inclusion Criteria:
Exclusion Criteria:
- Current signs or symptoms of infection, i.e., fever, hyperpnea, dyspnea, and palpitations.
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| Name | Affiliation | Role |
|---|---|---|
| Piyapong Prasertsri, Ph.D. | Burapha University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Allied Health Sciences, Burapha University | Mueang | Changwat Chon Buri | 20131 | Thailand |
There is no plan to make individual participant data available to other researchers.
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Participants were randomly divided into 2 groups consisting of 23 asparagus capsules and 21 placebo capsules groups.
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| Placebo capsule | Other | Placebo capsule is categorized as other. |
|
Concentration of blood protein carbonyl was measured in plasma in nmol/mg protein unit |
| Day 0 and end of 12 weeks |