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| Name | Class |
|---|---|
| Helse Møre og Romsdal HF | OTHER_GOV |
| Epax Norway AS | INDUSTRY |
| University of Manchester | OTHER |
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Atopic Dermatitis is associated with pronounced changes in the lipid composition in the skin. The lipid changes are influenced by and contributing to both the inflammatory circuit and the impaired barrier as well as changes in the skin microbiome This nutritional study will investigate the effect of long-chain monounsaturated fatty acid Cetoleic acid on atoptic dermatitis. Earlier studies have shown a anti-inflammatory effect of celoteic acid.
Women and men will be recruited to a placebo or a cetoleic-rich fish oil group and be examined for the effect on atopic dermatitis before, during and after the study period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LC-MUFA oil | Experimental | 2x1g capsules containing concentrated marine oil from north atlantic fish |
|
| Placebo | Placebo Comparator | 2x1g capsules containing corn oil |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LC-MUFA oil | Dietary Supplement | 2 x 1 g capsules containing marine oil from North Atlantic fish |
|
| Measure | Description | Time Frame |
|---|---|---|
| EASI | Change in EASI (Eczema Area and Serverity Index) POEM). | 6 months |
| DQLI | Change in DQLI | 6 months |
| POEM | Change in POEM (Patient Oriented Eczema Measure) | 6 months |
| Itch Numerical Rating Scale (NRS) | Change in experienced itch on average the last 24 hours, and how the worst itch in the past 24 hours was. Scale from 0 (no itch) to 10 (worst imaginable itch). | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Fatty acid composition in red blood cells | Determine the change in fatty acid composition in red blood cells | 6 months |
| Lipid compositions in skin | The change of ceramide/lipid composition in skin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lisa Kolden Midtbø, PhD | Contact | +47 70 11 16 00 | lisa.kolden.midtbo@moreforsking.no | |
| Jennifer Mildenberger, PhD | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Dag Arne Lihaug Hoff | Helse Møre og Romsdal HF | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helse Møre og Romsdal HF | Recruiting | Ålesund | Møre og Romsdal | 6017 | Norway |
Data will be presented as collective statistical data.
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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Interventions are given as 1g bovine capsules of equal size, weight and appearance, and provided in identical bottles with a coded label.
| Placebo | Dietary Supplement | 2 x 1 g capsules containing corn oil |
|
| 6 months |
| Inflammation in skin | The change in inflammatory signalling molecules in skin | 6 months |
| Blood lipids | The change in cholesterol/blood lipid profile | 6 months |
| TEWL | The change in trans-epidermal water loss (TEWL) | 6 months |
| Hydroxylated omega-3 fatty acids in plasma | The change of hydroxylated omega-3 fatty acids in plasma | 6 months |
| Omega-3 index with EASI parameters | The association of omega-3 index with EASI parameters | 6 months |
| Cetoleic acid with EASI parameters | The association of cetoleic acid content in RBCs with EASI parameters | 6 months |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |