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Investigators don't want to conduct this study as time is limited.
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| Name | Class |
|---|---|
| International Peace Maternity and Child Health Hospital | OTHER |
| Chinese Academy of Sciences | OTHER_GOV |
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This clinical trial will study the effects of PUFA supplementation during pregnancy and lactation period on fatty acid composition in human milk and plasma of the mothers and the clinical outcome of atopic dermatitis in infants at increased risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Docosahexaenoic Acid (DHA) | Experimental | infants receiving capsule containing DHA. |
|
| High Olive Oil | Other | infants receiving capsule without DHA and EPA. |
|
| DHA+EPA | Experimental | infants receiving capsule containing DHA and EPA. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DHA+EPA | Dietary Supplement |
| ||
| High Olive Oil |
| Measure | Description | Time Frame |
|---|---|---|
| Lipid Analysis | Baseline, Delivery, Within one week after delivery, 6 weeks postpartum, 4 months postpartum | |
| Metabolomics Study of PUFA | Baseline, Delivery, Within one week after delivery, 6 weeks postpartum, 4 months postpartum, 12 months postpartum | |
| Skin Prick Test to Common Allergens | 4 months postpartum, 12 months postpartum | |
| Clinical Assessment of IgE-mediated Allergic Eczema | 4 months postpartum, 12 months postpartum |
| Measure | Description | Time Frame |
|---|---|---|
| Fatty Acid Desaturase (FADS) Genotypes | Baseline | |
| immunoglobulin E immunoglobulin E Immunoglobulin E (IgE) Antibodies | Baseline | |
| Immunological Biomarkers |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zhiwei Liu, M.D. | International Peace Maternity and Child Health Hospital of China Welfare Institution | Principal Investigator |
| Huiyong Yin, Ph.D. | Chinese Academy of Sciences | Principal Investigator |
| Bryan Liu, Ph.D. | Mead Johnson & Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| International Peace Maternity and Child Health Hospital of China welfare Institute | Shanghai | Shanghai Municipality | 200030 | China |
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| ID | Term |
|---|---|
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
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|
| DHA | Dietary Supplement |
|
| 4 months postpartum, 12 months postpartum |
| Medically-confirmed adverse events collected throughout the study period | 12 months postpartum |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |