• CHina Adrenal Venous saMPling InvestigatiON

  NCT07252284

  RecruitingObservationalUpdated Nov 26, 2025
• Antecubital Versus Femoral Approach for Adrenal Venous Sampling

  NCT06029803

  Unknown statusInterventionalNot ApplicableUpdated Sep 8, 2023
• Adrenal Venous Sampling Via an Antecubital Approach

  NCT03778645

  Unknown statusObservationalUpdated Dec 21, 2018
• Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE)

  NCT07298954

  RecruitingInterventionalNot ApplicableUpdated Dec 24, 2025
• The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Approach

  NCT06737848

  Not yet recruitingInterventionalNot ApplicableUpdated Dec 17, 2024
• Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA)

  NCT04461535

  CompletedInterventionalNot ApplicableUpdated Dec 29, 2023

ClinicalTrials.gov ID

NCT06192238

Lead Sponsor

Chinese Academy of Medical Sciences, Fuwai HospitalOTHER

Overall Status

Not yet recruiting

Study Type

Observational

Enrollment

1,500Estimated

Last Update Posted

Jan 9, 2024Actual

Start Date

Jan 1, 2024Estimated

Primary Completion Date

Dec 30, 2026Estimated

Completion Date

Dec 30, 2026Estimated

Official Title

A National Multicenter Study of Adrenal Venous Sampling for the Subtype Diagnosis of Primary Aldosteronism in China

Brief Summary

This multicenter study intends to combine retrospective analysis and prospective registry to evaluate the success rate and safety of adrenal venous sampling (AVS) via antecubital and femoral approach for patients with primary aldosteronism. The consistency of AVS with pathological results and clinical outcomes, the factors affecting the success of AVS, and the optimal population for AVS will be aslo analyzed in this study.

Detailed Description

Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, and its most common subtypes are aldosterone-producing adenoma and idiopathic hyperaldosteronism, which account for 95% to 98% of PA. Subtype diagnosis is crucial for the treatment of primary aldosteronism, which conducts the appropriate treatment strategy. Currently, adrenal venous sampling (AVS) serves as the gold standard for subtyping of PA. How to improve the success rate of AVS has been a hot topic in the field of primary aldosteronism. This multicenter registry study intends to combine retrospective analysis and prospective registry to evaluate the success rate and safety of AVS via antecubital and femoral approach for patients with primary aldosteronism. The consistency of AVS with pathological results and clinical outcomes, the factors affecting the success of AVS, and the optimal population for AVS will be also analyzed in this study.

• Hyperaldosteronism

• adrenal venous sampling

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No data available

Eligibility Criteria

Inclusion Criteria:

1. Aged from 18 to 65 with no limits in sex;
2. Patients with confirmed primary aldosteronism;
3. Patients or their legal representatives sign written informed consent approved by the ethics committee；

Exclusion Criteria:

1. Severe comorbidity, including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, and metastatic tumor within the previous 3 months；
2. An estimated glomerular filtration rate <45 ml/min/1.73 m2, or serum creatinine >176 μmol/L；
3. Patients who refuse adrenalectomy;
4. Suspected of having an adrenocortical carcinoma;
5. Allergy to contrast agent;
6. Pregnant, nursing, or planning to become pregnant

Observational Model

Cohort

Time Perspective

Other

Lead Sponsor

Chinese Academy of Medical Sciences, Fuwai HospitalOTHER

zhangguijun1212@63.com86-0315-6272993

184530063@qq.com86-0371-56570913

598634874@qq.com86-0394-8521613

chengkang75@126.com86-029-61199240

tang5995@aliyun.com