Visual cues guide finger sequence movement by indicating which finger to move in alignment with the position and of the visual cue.

Change from baseline in task-based functional MRI activation (Blood Oxygen Level Dependent; BOLD) in the premotor cortex, examining the contrast (Cued Tapping vs Rest) at week 8.

Change from baseline in resting state connectivity will focus on nodes of auditory network and sensorimotor network strength in functional MRI activation at week 8

Motor performance on the cued motor sequence task across three time points (pre-post measurement visits of the 8-week training, and mid-trial at week 4 online) based on accuracy of the key presses. The number of correctly performed motor sequences and movement will be averaged for trained and untrained sequences.

Motor performance on the cued motor sequence task across three time points (pre-post measurement visits of the 8 week training, and mid-trial at week 4 online) based on the timing stability in synchrony with the onset of the cue. The number of correctly performed motor sequences and movement will be averaged.

Change from baseline to week 8 in scores of the Grooved Pegboard Task (measured in time in seconds) for both the dominant and non-dominant hand. A total of 240 seconds is the maximum allowed (minimum of 0), where a higher score indicates worse outcome.

Change from baseline to week 8 in scores of the Box and Block test (measured in number of blocks transferred in one minute, rule breaks are deducted) for both the dominant and non-dominant hand. A score of 150 is the maximum (minimum of 0), where a higher score indicates a better outcome.

Change from baseline to week 8 in scores of the Digit Span task (number of correctly recalled digits in a sequence is recorded), a maximum score of 2-9, with a higher score meaning a better outcome.

Change from baseline to week 8 in scores of the Digit Span task (number of correctly recalled digits in a sequence is recorded) with a score ranging from 2-8 and a higher score indicating better outcome.

Change from baseline to week 8 in scores of the Trail Making Test (measured in time over 5 trials). The final score is trial 4 (letter-switching) (score range: 0-240) minus the average of trials 1,2, 3, and 5 (Visual scanning, number sequencing, letter sequencing, and motor speed, respectively). The minimum possible score is 0 and the maximum is 240, where a higher score indicates a worse outcome.

Change from baseline to week 8 in scores of the Stroop Color Word Interference Test (the combined time during the two congruent trials is subtracted from the time during the non-congruent trial), the lowest possible score is 0 and the maximum is 180, where a higher score indicates a worse outcome.

Change from baseline to week 8 in scores of the Verbal Fluency Test (total number of correct responses across trials excluding repeats, and deducting errors for phonemic and categorical subtests are recorded), where a higher score indicates better performance, a minimum of 0 and a maximum of 480.

Change from baseline to week 8 in scores of the Rey Auditory Verbal-Learning Test, the number of correct responses is recorded for both immediate, interference and delayed recall trials, the final score is the highest achieved number on the learning trails (0 - 15) minus the delayed recall score (0 - 15), where a higher score indicates a worse outcome. The maximum score is 15 and the lowest is -15.

Change from baseline to week 8 in scores of the EuroQol- 5 (Dimensions: mobility, self-care, usual activity, pain/discomfort, and anxiety/depression) range from 1-5 where a higher number is a worse outcome, and a visual analogue scale from 0-100 where a higher number is a better outcome.

Change from baseline to week 8 in scores of the Depression Anxiety Stress Scale, where Depression symptoms related items: 3, 5, 10, 13, 16, 17, 21 (range from 0-21) Anxiety disorder-related items: 2, 4, 7, 9, 15, 19, 20 (range from 0-21) Stress-related items: 1, 6, 8, 11, 12, 14, 18 (range from 0-21), where a higher score indicates a worse outcome for all domains.

Change from baseline to week 8 in performance of the dual cognitive-motor interference task at week 8. Participants are asked to conduct a finger tapping task, and a letter counting task separately (Single Task condition), and a third trial in which participants are asked to perform both tasks simultaneously (Dual Task condition). Scores on the task will be compared at baseline and at week 8 by contrasting the role of the single tasks from the dual task and quantifying any decreases/interference related to the dual task, and comparing the two groups.

Changes (baseline to post training; within and between hemispheres contralateral to the trained vs. untrained hand) comparing fractional anisotropy, radial diffusivity, and mean diffusivity of the corticospinal tract between groups across the two timepoints, pre-and post-training in the hemisphere contralateral to the trained hand, and between the hemispheres.

Change in the strength of the associations (if any) between cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test), and self-report measures and trained tasks) and MRI changes in white matter diffusivity (as measured by fractional anisotropy of the left arcuate fasciculus measures) at baseline and at week 8.

Change in the strength of the associations (if any) between motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test) and MRI changes in white matter diffusivity (as measured by fractional anisotropy of the left arcuate fasciculus measures) at baseline and at week 8.

Change in the strength of the associations (if any) between self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number)) and MRI changes in white matter diffusivity (as measured by fractional anisotropy of the left arcuate fasciculus measures) at baseline and at week 8.

Change in the strength of the associations (if any) between performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue) and MRI changes in white matter diffusivity (as measured by fractional anisotropy of the left arcuate fasciculus measures) at baseline and at week 8.

Change in the strength of the associations (if any) between cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test), and self-report measures and trained tasks) and MRI changes in cortical thickness (measured as the distance between the white and the pial surfaces at each location of cortex) found at baseline and at week 8.

Change in the strength of the associations (if any) between motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test) and MRI changes in cortical thickness (measured as the distance between the white and the pial surfaces at each location of cortex) found at baseline and at week 8.

Change in the strength of the associations (if any) between self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number)) and MRI changes in cortical thickness (measured as the distance between the white and the pial surfaces at each location of cortex) found at baseline and at week 8.

Change in the strength of the associations (if any) between performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue) and MRI changes in cortical thickness (measured as the distance between the white and the pial surfaces at each location of cortex) found at baseline and at week 8.

Change in the strength of the associations (if any) between cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test), and task-based functional MRI activation in the premotor cortex, the following contrasts will be calculated (Cued Tapping vs Rest) found at baseline and at week 8.

Change in the strength of the associations (if any) between motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test) and task-based functional MRI activation in the premotor cortex, the following contrasts will be calculated (Cued Tapping vs Rest) found at baseline and at week 8.

Change in the strength of the associations (if any) between self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number)) and task-based functional MRI activation in the premotor cortex, the following contrasts will be calculated (Cued Tapping vs Rest) found at baseline and at week 8.

Change in the strength of the associations (if any) between performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue) and task-based functional MRI activation in the premotor cortex, the following contrasts will be calculated (Cued Tapping vs Rest) found at baseline and at week 8.

Change in the strength of the associations (if any) between cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test), and resting state connectivity will focus on nodes of auditory network and sensorimotor network strength in functional MRI activation at week 8 found at baseline and at week 8.

Change in the strength of the associations (if any) between motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test) and resting state connectivity will focus on nodes of auditory network and sensorimotor network strength in functional MRI activation at week 8 found at baseline and at week 8.

Change in the strength of the associations (if any) between self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number)) and resting state connectivity will focus on nodes of auditory network and sensorimotor network strength in functional MRI activation at week 8 found at baseline and at week 8.

Change in the strength of the associations (if any) between performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue) and resting state connectivity will focus on nodes of auditory network and sensorimotor network strength in functional MRI activation at week 8 found at baseline and at week 8.

Personality traits as measured by the Big Five-Short Form (administered at baseline) will be used as a covariate of changes from baseline to the 8-week timepoint in cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test).

Personality traits as measured by the Big Five-Short Form will be used as a covariate of changes from baseline to the 8-week timepoint in motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test).

Personality traits as measured by the Big Five-Short Form will be used as a covariate of changes from baseline to the 8-week timepoint in self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number))

Personality traits as measured by the Big Five-Short Form will be used as a covariate of changes from baseline to the 8-week timepoint in performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue).

We aim to assess the intrinsic motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) administered at the 8-week timepoint as a covariate of change from baseline to 8-week timepoint in cognitive measures (based on a composite score including scores from Digit Span Forward, Digit Span Backwards, Trail Making Test (inverted to indicate better outcome with higher number), Stroop Color Word Interference (inverted to indicate better outcome with higher number), Verbal Fluency Test, and the Rey Auditory Verbal-Learning Test).

We aim to assess the intrinsic motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) administered at the 8-week timepoint as a covariate of change from baseline to 8-week timepoint in motor measures (based on a composite score Grooved Pegboard Task (inverted to indicate better outcome with higher number), and Box and Blocks Test).

We aim to assess the intrinsic motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) administered at the 8-week timepoint as a covariate of change from baseline to 8-week timepoint in self-report measures (based on a composite score of Quality of Life measure (inverted to indicate better outcome with higher number), and its visual analogue scale, Depression Anxiety Stress Scale (inverted to indicate better outcome with higher number)).

We aim to assess the intrinsic motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) administered at the 8-week timepoint as a covariate of change from baseline to 8-week timepoint in performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue).

We seek to assess resting state connectivity in the nucleus accumbens (NAcc) with regions involved in music-reward as a proxy for motivation, namely superior temporal gyrus (STG), primary auditory cortex (A1), prefrontal cortex (PFC), the ventral striatum, and putamen while adding participant scores on the internal motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) as a covariate.

We seek to assess changes in fractional anisotropy as measure of white matter integrity using diffuse tensor imaging (DTI) of white matter tracts underlying regions linked to music reward (NAcc, STG, A1, PFC, ventral striatum, and putamen). Namely, uncinate fasciculus, arcuate fasciculus, corpus callosum, cingulate bundle, fronto-occipital fasciculus, anterior limb of internal capsule, and the anterior thalamic radiation. Participant scores on a scale assessing the internal motivation to engage in musical activities using the Barcelona Music Reward Questionnaire (BMRQ) will be added as a covariate.

Musical background as assessed with the Goldsmith Musical Sophistication Index (GMSI) will be used as covariate in the change from baseline to 8-week timepoint in performance on the trained tasks (measured by a composite score of the number of correctly performed motor sequences and timing stability in synchrony with the onset of the cue).