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The goal of this pilot interventional no-profit study is to evaluate airway pressure, esophageal pressure and variations in lung volume distribution with EIT in mechanically ventilated patients admitted to our UTI with respiratory failure after the application of an abdominal weight and resulting increase of intra-abdominal pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Abdominal Pressure Rise | Experimental | Application of an abdominal weight and record of respiratory mechanics data, intra-abdominal pressure variation, Electrical Impedance Tomography data |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Application of abdominal weight | Procedure | Application of variable weight on the abdomen to reach a 5 mmHg increase in IAP |
|
| Measure | Description | Time Frame |
|---|---|---|
| Variation of lung volume distribution | TID % | through study completion, an average of 1 year |
| Variation of airway pressure | cmH2O | through study completion, an average of 1 year |
| Variation of esophageal pressure | cmH2O | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paolo Persona, MD, PhD | Contact | +39 3389745902 | ppersona75@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliera Università di Padova | Recruiting | Padova | 35100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40380228 | Derived | Pacchiarini G, Pettenuzzo T, Zarantonello F, Sella N, Lumetti G, Boscolo A, De Cassai A, Cammarota G, Persona P, Navalesi P; LOVE BEER Study Group. The "mechanical paradox" unveiled: a physiological study. Crit Care. 2025 May 16;29(1):194. doi: 10.1186/s13054-025-05385-9. |
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
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