Clinical Study of Fecal Microbiota Transplantation in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)

To Investigate the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO).

Small intestinal bacterial overgrowth (SIBO) is defined as the presence of excessive numbers of bacteria in the small bowel causing gastrointestinal (GI) symptoms. These bacteria are usually coliforms, which are typically found in the colon and include predominantly Gram-negative aerobic and anaerobic species that ferment carbohydrates producing gas .Fecal Microbiota Transplantation (FMT) is a therapeutic method to transplant the microbiota from the feces of healthy people into the intestinal tract of patients. To explore the overall efficacy and safety of FMT in the treatment of SIBO.

Inclusion Criteria:

• Patients with a positive breath test result upon initial admission.
• Patients presenting with abdominal symptoms.
• Patients who have stool and small intestinal fluid samples available before and after FMT.

Exclusion Criteria:

• Patients with gastrointestinal malignancies.
• Patients with a history of gastrointestinal surgery.
• Patients on long-term probiotic use.
• Patients with a history of extensive antibiotic use.