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The purpose of this study is to examine the effects of a postural adjustment, targeted training program on balance ability and postural responses anticipatory postural adjustments (APA) and compensatory postural adjustments (CPA) in individuals with MS
All participants participated in individual training program aimed at improving balance ability and postural adjustments. The training program and individual activities were based on previously published programs and motor learning principles, and consists of 18, 1-hour training sessions over six weeks (3 sessions/week). Training occurred in person 2 days a week (in person training) and at home (home exercise program) 1 day a week, for a total of 3 sessions per week. The duration of training sessions were 60 minutes per session for a total of 1,140 minutes of training. The exercise room temperature was centrally regulated (23.3 degrees C).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Balance targeted exercises group | Experimental | participants in this group will receive the balance targeted exercises for up to 6 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Balance targeted exercises | Behavioral | 6-week exercise program, 3 sessions per week (2 sessions in person, 1 session of home exercises. Participants will receive a booklet with information about the home exercises and will receive a text message reminder), each session will last 60 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in balance ability as measured by the BESTest | The Balance Evaluation Systems Test (BESTest) will be used to measure balance ability. Items are scored from 0 (severe impairment) to 3 (no impairment), with a total score of 108. A higher score suggests better balance ability. | Baseline, 6 weeks (post intervention) |
| Change in reaction time | Measure in seconds | Baseline, 6 weeks (post intervention) |
| Change in movement velocity | Measure in degree per second | Baseline, 6 weeks (post intervention) |
| Change in endpoint excursion percentage | measure of endpoint excursion in a percentage out of a100 | Baseline, 6 weeks (post intervention) |
| Change in directional control percentage | measure of directional control in a percentage out of a100 | Baseline, 6 weeks (post intervention) |
| Change in maximum excursion percentage | measure of maximum excursion in a percentage out of a100 | Baseline, 6 weeks (post intervention) |
| Change in muscle responses latency as measured by MCT | The Motor Control test (MCT) measures the subject's ability to generate a motor response latency to a sudden surface translation in a forward and backward direction at three different magnitudes (small, medium, and large). Latency: The time-lapse between the perturbation onset and the subject response for each limb. The latency is reported in milliseconds. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in balance confidence as measured by ABC | The Activities Specific Balance Confidence (ABC) scale is a self-report questionnaire of a subject's perceived level of balance confidence. It measures the subject's confidence in performing various ambulatory activities without falling. There are 16 items scored using a scale(0-100) with higher scores indicating more confidence in performing the tasks. A total score is reported by dividing the total ABC score by 16. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| James Moore, PhD | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami | Miami | Florida | 33136 | United States |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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|
| Baseline, 6 weeks (post intervention) |
| Change in postural muscles responses latency as measured by Electromyography (EMG) | Postural muscles responses onset latency in seconds | Baseline, 6 weeks (post intervention) |
| Change in APA as measured by microvolts | Postural muscles APA measured in microvolts | Baseline, 6 weeks (post intervention) |
| Change in CPA as measured by microvolts | Postural muscles CPA in microvolts | Baseline, 6 weeks (post intervention) |
| Baseline, 6 weeks (post intervention) |
| Change in quality of life as measured by the MSQoL-54 | Multiple Sclerosis Quality of Life - 54 (MSQoL-54) is a self-report questionnaire measuring subject perceived of quality of life. In total, it contains 54 items with a total score ranging from 0-100, with higher scores indicating a better quality of life | Baseline, 6 weeks (post intervention) |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |