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Comparison of corneal topography based on oct OCT principle (CASIA2) with Pentacam and Scheimpflug-based biomechanical devices (Corvis ST) in screening and diagnosing keratoconus; and evaluation of the consistency with Pentacam in measuring corneal parameters (such as curvature and thickness).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal control group |
| ||
| Subclinical keratoconus |
| ||
| Keratoconus |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pentacam, Corvis ST and CASIA2 | Other | morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST |
|
| Measure | Description | Time Frame |
|---|---|---|
| screening and diagnosis ability | Evaluate the sensitivity and specificity of parameters measured by CASIA2, Pentacam in diagnosing keratoconus using Receiver operating characteristic curves (ROC), and compare the Ectasia Screening Similarity（ESS）and D-value diagnostic efficacy using Area under the ROC curve (AUROC). Use the Delong test to compare the accuracy of various parameters in diagnosing early keratoconus. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement consistency | The independent sample T-test is used to compare inter- group differences in baseline data. Use independent sample T-test and One-way ANOVA to evaluate the consistency of the measurement results (anterior and posterior corneal curvature, corneal refractive index, CCT) obtained by CASIA2 and Pentacam.Finally, the ultimate outcome（such ad：K1 K2 KMax CCT） indicates that the P-value between the two devices is less than 0.05 and ICC-value is more than 0.75. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients premedicated for refractive surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shuangcheng Li, Master | Contact | 022-27313336-7539 | lscdoc@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yan Wang, Prof | Tiajin Eye Hospita | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tiajin Eye Hospital | Recruiting | Tianjin | Tianjin Municipality | China |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| one year |